Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children
BACKGROUND: Emerging evidence suggests that prenatal or early-life exposures to environmental contaminants may contribute to an increased risk of asthma and allergies in children. We aimed to the explore associations of prenatal exposures to a large set of environmental chemical contaminants with as...
Published in: | Allergy |
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2015
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Online Access: | https://curis.ku.dk/portal/da/publications/prenatal-exposure-to-environmental-chemical-contaminants-and-asthma-and-eczema-in-schoolage-children(1600d3f9-e763-4bca-9eb5-c6db7dbdfaed).html https://doi.org/10.1111/all.12605 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/1600d3f9-e763-4bca-9eb5-c6db7dbdfaed 2023-10-25T01:39:06+02:00 Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children Smit, L A M Lenters, V Høyer, B B Lindh, C H Pedersen, H S Liermontova, I Jönsson, B A G Piersma, A H Bonde, J P Toft, G Vermeulen, R Heederik, D 2015 https://curis.ku.dk/portal/da/publications/prenatal-exposure-to-environmental-chemical-contaminants-and-asthma-and-eczema-in-schoolage-children(1600d3f9-e763-4bca-9eb5-c6db7dbdfaed).html https://doi.org/10.1111/all.12605 eng eng info:eu-repo/semantics/closedAccess Smit , L A M , Lenters , V , Høyer , B B , Lindh , C H , Pedersen , H S , Liermontova , I , Jönsson , B A G , Piersma , A H , Bonde , J P , Toft , G , Vermeulen , R & Heederik , D 2015 , ' Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children ' , Allergy , vol. 70 , no. 6 , pp. 653-660 . https://doi.org/10.1111/all.12605 Asthma Child Preschool Cohort Studies Dichlorodiphenyl Dichloroethylene Diethylhexyl Phthalate Eczema Environmental Exposure Environmental Pollutants Female Greenland Humans Hydrocarbons Chlorinated Male Phthalic Acids Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects Principal Component Analysis Respiratory Sounds Ukraine article 2015 ftcopenhagenunip https://doi.org/10.1111/all.12605 2023-09-27T23:00:36Z BACKGROUND: Emerging evidence suggests that prenatal or early-life exposures to environmental contaminants may contribute to an increased risk of asthma and allergies in children. We aimed to the explore associations of prenatal exposures to a large set of environmental chemical contaminants with asthma and eczema in school-age children. METHODS: We studied 1024 mother-child pairs from Greenland and Ukraine from the INUENDO birth cohort. Data were collected by means of an interview-based questionnaire when the children were 5-9 years of age. Questions from the ISAAC study were used to define asthma, eczema, and wheeze. We applied principal components analysis (PCA) to sixteen contaminants in maternal serum sampled during pregnancy, including perfluoroalkyl substances (PFASs), metabolites of diethylhexyl (DEHP) and diisononyl (DiNP) phthalates, PCB-153, and p,p'-DDE. Scores of five principal components (PCs) explaining 70% of the variance were included in multiple logistic regression models. RESULTS: In a meta-analysis that included both populations, the PC2 score, reflecting exposure to DiNP, was negatively associated with current eczema (OR 0.71, 95% CI 0.52-0.96). Other associations were not consistent between the two populations. In Ukrainian children, the PC3 score (DEHP) was positively associated with current wheeze (adjusted OR 1.56, 95% CI 1.03-2.37), whereas the PC5 score, dominated by perfluorooctanoic acid (PFOA), was inversely associated with current wheeze (OR 0.64, 0.41-0.99). In Greenlandic children, a negative association of PC4 (organochlorines) with ever eczema (OR 0.78, 0.61-0.99) was found. CONCLUSIONS: We found limited evidence to support a link between prenatal exposure to environmental chemical contaminants and childhood asthma and eczema. Article in Journal/Newspaper Greenland greenlandic University of Copenhagen: Research Greenland Allergy 70 6 653 660 |
institution |
Open Polar |
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University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Asthma Child Preschool Cohort Studies Dichlorodiphenyl Dichloroethylene Diethylhexyl Phthalate Eczema Environmental Exposure Environmental Pollutants Female Greenland Humans Hydrocarbons Chlorinated Male Phthalic Acids Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects Principal Component Analysis Respiratory Sounds Ukraine |
spellingShingle |
Asthma Child Preschool Cohort Studies Dichlorodiphenyl Dichloroethylene Diethylhexyl Phthalate Eczema Environmental Exposure Environmental Pollutants Female Greenland Humans Hydrocarbons Chlorinated Male Phthalic Acids Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects Principal Component Analysis Respiratory Sounds Ukraine Smit, L A M Lenters, V Høyer, B B Lindh, C H Pedersen, H S Liermontova, I Jönsson, B A G Piersma, A H Bonde, J P Toft, G Vermeulen, R Heederik, D Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children |
topic_facet |
Asthma Child Preschool Cohort Studies Dichlorodiphenyl Dichloroethylene Diethylhexyl Phthalate Eczema Environmental Exposure Environmental Pollutants Female Greenland Humans Hydrocarbons Chlorinated Male Phthalic Acids Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects Principal Component Analysis Respiratory Sounds Ukraine |
description |
BACKGROUND: Emerging evidence suggests that prenatal or early-life exposures to environmental contaminants may contribute to an increased risk of asthma and allergies in children. We aimed to the explore associations of prenatal exposures to a large set of environmental chemical contaminants with asthma and eczema in school-age children. METHODS: We studied 1024 mother-child pairs from Greenland and Ukraine from the INUENDO birth cohort. Data were collected by means of an interview-based questionnaire when the children were 5-9 years of age. Questions from the ISAAC study were used to define asthma, eczema, and wheeze. We applied principal components analysis (PCA) to sixteen contaminants in maternal serum sampled during pregnancy, including perfluoroalkyl substances (PFASs), metabolites of diethylhexyl (DEHP) and diisononyl (DiNP) phthalates, PCB-153, and p,p'-DDE. Scores of five principal components (PCs) explaining 70% of the variance were included in multiple logistic regression models. RESULTS: In a meta-analysis that included both populations, the PC2 score, reflecting exposure to DiNP, was negatively associated with current eczema (OR 0.71, 95% CI 0.52-0.96). Other associations were not consistent between the two populations. In Ukrainian children, the PC3 score (DEHP) was positively associated with current wheeze (adjusted OR 1.56, 95% CI 1.03-2.37), whereas the PC5 score, dominated by perfluorooctanoic acid (PFOA), was inversely associated with current wheeze (OR 0.64, 0.41-0.99). In Greenlandic children, a negative association of PC4 (organochlorines) with ever eczema (OR 0.78, 0.61-0.99) was found. CONCLUSIONS: We found limited evidence to support a link between prenatal exposure to environmental chemical contaminants and childhood asthma and eczema. |
format |
Article in Journal/Newspaper |
author |
Smit, L A M Lenters, V Høyer, B B Lindh, C H Pedersen, H S Liermontova, I Jönsson, B A G Piersma, A H Bonde, J P Toft, G Vermeulen, R Heederik, D |
author_facet |
Smit, L A M Lenters, V Høyer, B B Lindh, C H Pedersen, H S Liermontova, I Jönsson, B A G Piersma, A H Bonde, J P Toft, G Vermeulen, R Heederik, D |
author_sort |
Smit, L A M |
title |
Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children |
title_short |
Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children |
title_full |
Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children |
title_fullStr |
Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children |
title_full_unstemmed |
Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children |
title_sort |
prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children |
publishDate |
2015 |
url |
https://curis.ku.dk/portal/da/publications/prenatal-exposure-to-environmental-chemical-contaminants-and-asthma-and-eczema-in-schoolage-children(1600d3f9-e763-4bca-9eb5-c6db7dbdfaed).html https://doi.org/10.1111/all.12605 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlandic |
genre_facet |
Greenland greenlandic |
op_source |
Smit , L A M , Lenters , V , Høyer , B B , Lindh , C H , Pedersen , H S , Liermontova , I , Jönsson , B A G , Piersma , A H , Bonde , J P , Toft , G , Vermeulen , R & Heederik , D 2015 , ' Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children ' , Allergy , vol. 70 , no. 6 , pp. 653-660 . https://doi.org/10.1111/all.12605 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1111/all.12605 |
container_title |
Allergy |
container_volume |
70 |
container_issue |
6 |
container_start_page |
653 |
op_container_end_page |
660 |
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1780734274973990912 |