Plasma levels of mannose-binding lectin and future risk of venous thromboembolism
Background: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both hig...
Published in: | Journal of Thrombosis and Haemostasis |
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Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2019
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Online Access: | https://curis.ku.dk/portal/da/publications/plasma-levels-of-mannosebinding-lectin-and-future-risk-of-venous-thromboembolism(1573a78a-37a6-417b-9993-28db4fd5628e).html https://doi.org/10.1111/jth.14539 https://curis.ku.dk/ws/files/236218642/Liang_et_al_2019_Journal_of_Thrombosis_and_Haemostasis.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/1573a78a-37a6-417b-9993-28db4fd5628e 2024-06-09T07:49:59+00:00 Plasma levels of mannose-binding lectin and future risk of venous thromboembolism Liang, Robin A. Høiland, Ina I. Ueland, Thor Aukrust, Pål Snir, Omri Hindberg, Kristian Brækkan, Sigrid K. Garred, Peter Mollnes, Tom E. Hansen, John Bjarne 2019 application/pdf https://curis.ku.dk/portal/da/publications/plasma-levels-of-mannosebinding-lectin-and-future-risk-of-venous-thromboembolism(1573a78a-37a6-417b-9993-28db4fd5628e).html https://doi.org/10.1111/jth.14539 https://curis.ku.dk/ws/files/236218642/Liang_et_al_2019_Journal_of_Thrombosis_and_Haemostasis.pdf eng eng info:eu-repo/semantics/openAccess Liang , R A , Høiland , I I , Ueland , T , Aukrust , P , Snir , O , Hindberg , K , Brækkan , S K , Garred , P , Mollnes , T E & Hansen , J B 2019 , ' Plasma levels of mannose-binding lectin and future risk of venous thromboembolism ' , Journal of Thrombosis and Haemostasis , vol. 17 , no. 10 , pp. 1661-1669 . https://doi.org/10.1111/jth.14539 complement deep vein thrombosis mannose-binding lectin pulmonary embolism venous thromboembolism article 2019 ftcopenhagenunip https://doi.org/10.1111/jth.14539 2024-05-16T11:29:17Z Background: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives: To investigate the association between plasma MBL levels and future risk of incident VTE. Methods: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular. Article in Journal/Newspaper Tromsø University of Copenhagen: Research Tromsø Journal of Thrombosis and Haemostasis 17 10 1661 1669 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
complement deep vein thrombosis mannose-binding lectin pulmonary embolism venous thromboembolism |
spellingShingle |
complement deep vein thrombosis mannose-binding lectin pulmonary embolism venous thromboembolism Liang, Robin A. Høiland, Ina I. Ueland, Thor Aukrust, Pål Snir, Omri Hindberg, Kristian Brækkan, Sigrid K. Garred, Peter Mollnes, Tom E. Hansen, John Bjarne Plasma levels of mannose-binding lectin and future risk of venous thromboembolism |
topic_facet |
complement deep vein thrombosis mannose-binding lectin pulmonary embolism venous thromboembolism |
description |
Background: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives: To investigate the association between plasma MBL levels and future risk of incident VTE. Methods: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular. |
format |
Article in Journal/Newspaper |
author |
Liang, Robin A. Høiland, Ina I. Ueland, Thor Aukrust, Pål Snir, Omri Hindberg, Kristian Brækkan, Sigrid K. Garred, Peter Mollnes, Tom E. Hansen, John Bjarne |
author_facet |
Liang, Robin A. Høiland, Ina I. Ueland, Thor Aukrust, Pål Snir, Omri Hindberg, Kristian Brækkan, Sigrid K. Garred, Peter Mollnes, Tom E. Hansen, John Bjarne |
author_sort |
Liang, Robin A. |
title |
Plasma levels of mannose-binding lectin and future risk of venous thromboembolism |
title_short |
Plasma levels of mannose-binding lectin and future risk of venous thromboembolism |
title_full |
Plasma levels of mannose-binding lectin and future risk of venous thromboembolism |
title_fullStr |
Plasma levels of mannose-binding lectin and future risk of venous thromboembolism |
title_full_unstemmed |
Plasma levels of mannose-binding lectin and future risk of venous thromboembolism |
title_sort |
plasma levels of mannose-binding lectin and future risk of venous thromboembolism |
publishDate |
2019 |
url |
https://curis.ku.dk/portal/da/publications/plasma-levels-of-mannosebinding-lectin-and-future-risk-of-venous-thromboembolism(1573a78a-37a6-417b-9993-28db4fd5628e).html https://doi.org/10.1111/jth.14539 https://curis.ku.dk/ws/files/236218642/Liang_et_al_2019_Journal_of_Thrombosis_and_Haemostasis.pdf |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Liang , R A , Høiland , I I , Ueland , T , Aukrust , P , Snir , O , Hindberg , K , Brækkan , S K , Garred , P , Mollnes , T E & Hansen , J B 2019 , ' Plasma levels of mannose-binding lectin and future risk of venous thromboembolism ' , Journal of Thrombosis and Haemostasis , vol. 17 , no. 10 , pp. 1661-1669 . https://doi.org/10.1111/jth.14539 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1111/jth.14539 |
container_title |
Journal of Thrombosis and Haemostasis |
container_volume |
17 |
container_issue |
10 |
container_start_page |
1661 |
op_container_end_page |
1669 |
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