Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.)
Steatosis and inflammation have been common gut symptoms in Atlantic salmon fed plant rich diets. Choline has recently been identified as essential for salmon in seawater, and β-glucan and nucleotides are frequently used to prevent inflammation. The study is aimed at documenting whether increased fi...
Published in: | Aquaculture Nutrition |
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Language: | English |
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2023
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Online Access: | https://curis.ku.dk/portal/da/publications/dietary-fish-meal-level-and-a-package-of-choline-glucan-and-nucleotides-modulate-gut-function-microbiota-and-health-in-atlantic-salmon-salmo-salar-l(1192bf09-e981-4a08-8740-4236d4084054).html https://doi.org/10.1155/2023/5422035 https://curis.ku.dk/ws/files/336469101/Dietary_Fish_Meal_Level_and_a_Package_of_Choline.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/1192bf09-e981-4a08-8740-4236d4084054 2024-06-09T07:44:45+00:00 Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) Krogdahl, Åshild Chikwati, Elvis M. Krasnov, Aleksei Dhanasiri, Anusha Berge, Gerd M. Aru, Violetta Khakimov, Bekzod Engelsen, Søren Balling Vinje, Hilde Kortner, Trond M. 2023 application/pdf https://curis.ku.dk/portal/da/publications/dietary-fish-meal-level-and-a-package-of-choline-glucan-and-nucleotides-modulate-gut-function-microbiota-and-health-in-atlantic-salmon-salmo-salar-l(1192bf09-e981-4a08-8740-4236d4084054).html https://doi.org/10.1155/2023/5422035 https://curis.ku.dk/ws/files/336469101/Dietary_Fish_Meal_Level_and_a_Package_of_Choline.pdf eng eng info:eu-repo/semantics/openAccess Krogdahl , Å , Chikwati , E M , Krasnov , A , Dhanasiri , A , Berge , G M , Aru , V , Khakimov , B , Engelsen , S B , Vinje , H & Kortner , T M 2023 , ' Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) ' , Aquaculture Nutrition , vol. 2023 , 5422035 . https://doi.org/10.1155/2023/5422035 article 2023 ftcopenhagenunip https://doi.org/10.1155/2023/5422035 2024-05-16T11:29:28Z Steatosis and inflammation have been common gut symptoms in Atlantic salmon fed plant rich diets. Choline has recently been identified as essential for salmon in seawater, and β-glucan and nucleotides are frequently used to prevent inflammation. The study is aimed at documenting whether increased fishmeal (FM) levels (8 levels from 0 to 40%) and supplementation (Suppl) with a mixture of choline (3.0 g/kg), β-glucan (0.5 g/kg), and nucleotides (0.5 g/kg) might reduce the symptoms. Salmon (186 g) were fed for 62 days in 16 saltwater tanks before samples were taken from 12 fish per tank for observation of biochemical, molecular, metabolome, and microbiome indicators of function and health. Steatosis but no inflammation was observed. Lipid digestibility increased and steatosis decreased with increasing FM levels and supplementation, seemingly related to choline level. Blood metabolites confirmed this picture. Genes in intestinal tissue affected by FM levels are mainly involved in metabolic and structural functions. Only a few are immune genes. The supplement reduced these FM effects. In gut digesta, increasing FM levels increased microbial richness and diversity, and changed the composition, but only for unsupplemented diets. An average choline requirement of 3.5 g/kg was indicated for Atlantic salmon at the present life stage and under the present condition. Article in Journal/Newspaper Atlantic salmon Salmo salar University of Copenhagen: Research Aquaculture Nutrition 2023 1 29 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
Steatosis and inflammation have been common gut symptoms in Atlantic salmon fed plant rich diets. Choline has recently been identified as essential for salmon in seawater, and β-glucan and nucleotides are frequently used to prevent inflammation. The study is aimed at documenting whether increased fishmeal (FM) levels (8 levels from 0 to 40%) and supplementation (Suppl) with a mixture of choline (3.0 g/kg), β-glucan (0.5 g/kg), and nucleotides (0.5 g/kg) might reduce the symptoms. Salmon (186 g) were fed for 62 days in 16 saltwater tanks before samples were taken from 12 fish per tank for observation of biochemical, molecular, metabolome, and microbiome indicators of function and health. Steatosis but no inflammation was observed. Lipid digestibility increased and steatosis decreased with increasing FM levels and supplementation, seemingly related to choline level. Blood metabolites confirmed this picture. Genes in intestinal tissue affected by FM levels are mainly involved in metabolic and structural functions. Only a few are immune genes. The supplement reduced these FM effects. In gut digesta, increasing FM levels increased microbial richness and diversity, and changed the composition, but only for unsupplemented diets. An average choline requirement of 3.5 g/kg was indicated for Atlantic salmon at the present life stage and under the present condition. |
format |
Article in Journal/Newspaper |
author |
Krogdahl, Åshild Chikwati, Elvis M. Krasnov, Aleksei Dhanasiri, Anusha Berge, Gerd M. Aru, Violetta Khakimov, Bekzod Engelsen, Søren Balling Vinje, Hilde Kortner, Trond M. |
spellingShingle |
Krogdahl, Åshild Chikwati, Elvis M. Krasnov, Aleksei Dhanasiri, Anusha Berge, Gerd M. Aru, Violetta Khakimov, Bekzod Engelsen, Søren Balling Vinje, Hilde Kortner, Trond M. Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) |
author_facet |
Krogdahl, Åshild Chikwati, Elvis M. Krasnov, Aleksei Dhanasiri, Anusha Berge, Gerd M. Aru, Violetta Khakimov, Bekzod Engelsen, Søren Balling Vinje, Hilde Kortner, Trond M. |
author_sort |
Krogdahl, Åshild |
title |
Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) |
title_short |
Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) |
title_full |
Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) |
title_fullStr |
Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) |
title_full_unstemmed |
Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) |
title_sort |
dietary fish meal level and a package of choline, β -glucan, and nucleotides modulate gut function, microbiota, and health in atlantic salmon ( salmo salar , l.) |
publishDate |
2023 |
url |
https://curis.ku.dk/portal/da/publications/dietary-fish-meal-level-and-a-package-of-choline-glucan-and-nucleotides-modulate-gut-function-microbiota-and-health-in-atlantic-salmon-salmo-salar-l(1192bf09-e981-4a08-8740-4236d4084054).html https://doi.org/10.1155/2023/5422035 https://curis.ku.dk/ws/files/336469101/Dietary_Fish_Meal_Level_and_a_Package_of_Choline.pdf |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Krogdahl , Å , Chikwati , E M , Krasnov , A , Dhanasiri , A , Berge , G M , Aru , V , Khakimov , B , Engelsen , S B , Vinje , H & Kortner , T M 2023 , ' Dietary Fish Meal Level and a Package of Choline, β -Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon ( Salmo salar , L.) ' , Aquaculture Nutrition , vol. 2023 , 5422035 . https://doi.org/10.1155/2023/5422035 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1155/2023/5422035 |
container_title |
Aquaculture Nutrition |
container_volume |
2023 |
container_start_page |
1 |
op_container_end_page |
29 |
_version_ |
1801373553320263680 |