Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions
Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and con...
Published in: | Reproductive Toxicology |
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Language: | English |
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2012
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Online Access: | https://curis.ku.dk/portal/da/publications/sperm-dna-integrity-in-relation-to-exposure-to-environmental-perfluoroalkyl-substances--a-study-of-spouses-of-pregnant-women-in-three-geographical-regions(116c978c-729b-416b-aade-3815b13828c6).html https://doi.org/10.1016/j.reprotox.2012.02.008 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/116c978c-729b-416b-aade-3815b13828c6 2024-02-27T08:41:05+00:00 Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions Specht, Ina Olmer Hougaard, Karin S Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Lindh, Christian H Toft, Gunnar Jönsson, Bo A G Giwercman, Aleksander Bonde, Jens Peter E 2012 https://curis.ku.dk/portal/da/publications/sperm-dna-integrity-in-relation-to-exposure-to-environmental-perfluoroalkyl-substances--a-study-of-spouses-of-pregnant-women-in-three-geographical-regions(116c978c-729b-416b-aade-3815b13828c6).html https://doi.org/10.1016/j.reprotox.2012.02.008 eng eng info:eu-repo/semantics/restrictedAccess Specht , I O , Hougaard , K S , Spanò , M , Bizzaro , D , Manicardi , G C , Lindh , C H , Toft , G , Jönsson , B A G , Giwercman , A & Bonde , J P E 2012 , ' Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions ' , Reproductive Toxicology , vol. 33 , no. 4 , pp. 577-83 . https://doi.org/10.1016/j.reprotox.2012.02.008 article 2012 ftcopenhagenunip https://doi.org/10.1016/j.reprotox.2012.02.008 2024-02-01T00:02:01Z Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrent DNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptor and Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptotic markers or reproductive hormones emerged. We observed a slight increase in SHBG and TUNEL-positivity with increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposure interferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found. Article in Journal/Newspaper Greenland University of Copenhagen: Research Greenland Reproductive Toxicology 33 4 577 583 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrent DNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptor and Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptotic markers or reproductive hormones emerged. We observed a slight increase in SHBG and TUNEL-positivity with increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposure interferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found. |
format |
Article in Journal/Newspaper |
author |
Specht, Ina Olmer Hougaard, Karin S Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Lindh, Christian H Toft, Gunnar Jönsson, Bo A G Giwercman, Aleksander Bonde, Jens Peter E |
spellingShingle |
Specht, Ina Olmer Hougaard, Karin S Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Lindh, Christian H Toft, Gunnar Jönsson, Bo A G Giwercman, Aleksander Bonde, Jens Peter E Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions |
author_facet |
Specht, Ina Olmer Hougaard, Karin S Spanò, Marcello Bizzaro, Davide Manicardi, Gian Carlo Lindh, Christian H Toft, Gunnar Jönsson, Bo A G Giwercman, Aleksander Bonde, Jens Peter E |
author_sort |
Specht, Ina Olmer |
title |
Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions |
title_short |
Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions |
title_full |
Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions |
title_fullStr |
Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions |
title_full_unstemmed |
Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions |
title_sort |
sperm dna integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions |
publishDate |
2012 |
url |
https://curis.ku.dk/portal/da/publications/sperm-dna-integrity-in-relation-to-exposure-to-environmental-perfluoroalkyl-substances--a-study-of-spouses-of-pregnant-women-in-three-geographical-regions(116c978c-729b-416b-aade-3815b13828c6).html https://doi.org/10.1016/j.reprotox.2012.02.008 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Specht , I O , Hougaard , K S , Spanò , M , Bizzaro , D , Manicardi , G C , Lindh , C H , Toft , G , Jönsson , B A G , Giwercman , A & Bonde , J P E 2012 , ' Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions ' , Reproductive Toxicology , vol. 33 , no. 4 , pp. 577-83 . https://doi.org/10.1016/j.reprotox.2012.02.008 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.reprotox.2012.02.008 |
container_title |
Reproductive Toxicology |
container_volume |
33 |
container_issue |
4 |
container_start_page |
577 |
op_container_end_page |
583 |
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1792048346896007168 |