Ancient human genome sequence of an extinct Palaeo-Eskimo
We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an am...
Published in: | Nature |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2010
|
Subjects: | |
Online Access: | https://curis.ku.dk/portal/da/publications/ancient-human-genome-sequence-of-an-extinct-palaeoeskimo(0cb4bd08-2d6a-4b06-bf5d-cb3a24bdab37).html https://doi.org/10.1038/nature08835 https://curis.ku.dk/ws/files/282937611/Ancient_human_genome_sequence_of_an_extinct_Palaeo_Eskimo_publisher_version_.pdf |
id |
ftcopenhagenunip:oai:pure.atira.dk:publications/0cb4bd08-2d6a-4b06-bf5d-cb3a24bdab37 |
---|---|
record_format |
openpolar |
spelling |
ftcopenhagenunip:oai:pure.atira.dk:publications/0cb4bd08-2d6a-4b06-bf5d-cb3a24bdab37 2024-04-14T08:11:11+00:00 Ancient human genome sequence of an extinct Palaeo-Eskimo Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, Tom Wang, Yong Raghavan, Maanasa Campos, Paula Kamp, Hanne Louise Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline Binladen, Jonas Khalid Mohamed Awad Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Antoine Alexandre Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F. G. Ramsey, Christopher Bronk Hansen, Thomas van Overeem Nielsen, Finn Cilius Crawford, Michael H. Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Wang, Jun Willerslev, Eske 2010-02-11 application/pdf https://curis.ku.dk/portal/da/publications/ancient-human-genome-sequence-of-an-extinct-palaeoeskimo(0cb4bd08-2d6a-4b06-bf5d-cb3a24bdab37).html https://doi.org/10.1038/nature08835 https://curis.ku.dk/ws/files/282937611/Ancient_human_genome_sequence_of_an_extinct_Palaeo_Eskimo_publisher_version_.pdf eng eng info:eu-repo/semantics/openAccess Rasmussen , M , Li , Y , Lindgreen , S , Pedersen , J S , Albrechtsen , A , Moltke , I , Metspalu , M , Metspalu , E , Kivisild , T , Gupta , R , Bertalan , M , Nielsen , K , Gilbert , T , Wang , Y , Raghavan , M , Campos , P , Kamp , H L M , Wilson , A S , Gledhill , A , Tridico , S , Bunce , M , Lorenzen , E , Binladen , J K M A , Guo , X , Zhao , J , Zhang , X , Zhang , H , Li , Z , Chen , M , Orlando , L A A , Kristiansen , K , Bak , M , Tommerup , N , Bendixen , C , Pierre , T L , Grønnow , B , Meldgaard , M , Andreasen , C , Fedorova , S A , Osipova , L P , Higham , T F G , Ramsey , C B , Hansen , T V O , Nielsen , F C , Crawford , M H , Brunak , S , Sicheritz-Pontén , T , Villems , R , Nielsen , R , Krogh , A , Wang , J & Willerslev , E 2010 , ' Ancient human genome sequence of an extinct Palaeo-Eskimo ' , Nature , vol. 463 , no. 7282 , pp. 757-762 . https://doi.org/10.1038/nature08835 Cryopreservation Emigration and Immigration Extinction Biological Genetics Population Genome Human Genomics Genotype Greenland Hair History Ancient Humans Inuits Male Phenotype Phylogeny Polymorphism Single Nucleotide Sequence Analysis DNA Siberia article 2010 ftcopenhagenunip https://doi.org/10.1038/nature08835 2024-03-21T17:28:07Z We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. Article in Journal/Newspaper eskimo* Greenland inuit inuits permafrost Siberia University of Copenhagen: Research Greenland Nature 463 7282 757 762 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Cryopreservation Emigration and Immigration Extinction Biological Genetics Population Genome Human Genomics Genotype Greenland Hair History Ancient Humans Inuits Male Phenotype Phylogeny Polymorphism Single Nucleotide Sequence Analysis DNA Siberia |
spellingShingle |
Cryopreservation Emigration and Immigration Extinction Biological Genetics Population Genome Human Genomics Genotype Greenland Hair History Ancient Humans Inuits Male Phenotype Phylogeny Polymorphism Single Nucleotide Sequence Analysis DNA Siberia Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, Tom Wang, Yong Raghavan, Maanasa Campos, Paula Kamp, Hanne Louise Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline Binladen, Jonas Khalid Mohamed Awad Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Antoine Alexandre Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F. G. Ramsey, Christopher Bronk Hansen, Thomas van Overeem Nielsen, Finn Cilius Crawford, Michael H. Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Wang, Jun Willerslev, Eske Ancient human genome sequence of an extinct Palaeo-Eskimo |
topic_facet |
Cryopreservation Emigration and Immigration Extinction Biological Genetics Population Genome Human Genomics Genotype Greenland Hair History Ancient Humans Inuits Male Phenotype Phylogeny Polymorphism Single Nucleotide Sequence Analysis DNA Siberia |
description |
We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. |
format |
Article in Journal/Newspaper |
author |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, Tom Wang, Yong Raghavan, Maanasa Campos, Paula Kamp, Hanne Louise Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline Binladen, Jonas Khalid Mohamed Awad Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Antoine Alexandre Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F. G. Ramsey, Christopher Bronk Hansen, Thomas van Overeem Nielsen, Finn Cilius Crawford, Michael H. Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Wang, Jun Willerslev, Eske |
author_facet |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, Tom Wang, Yong Raghavan, Maanasa Campos, Paula Kamp, Hanne Louise Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline Binladen, Jonas Khalid Mohamed Awad Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Antoine Alexandre Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F. G. Ramsey, Christopher Bronk Hansen, Thomas van Overeem Nielsen, Finn Cilius Crawford, Michael H. Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Wang, Jun Willerslev, Eske |
author_sort |
Rasmussen, Morten |
title |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_short |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_fullStr |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full_unstemmed |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_sort |
ancient human genome sequence of an extinct palaeo-eskimo |
publishDate |
2010 |
url |
https://curis.ku.dk/portal/da/publications/ancient-human-genome-sequence-of-an-extinct-palaeoeskimo(0cb4bd08-2d6a-4b06-bf5d-cb3a24bdab37).html https://doi.org/10.1038/nature08835 https://curis.ku.dk/ws/files/282937611/Ancient_human_genome_sequence_of_an_extinct_Palaeo_Eskimo_publisher_version_.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland inuit inuits permafrost Siberia |
genre_facet |
eskimo* Greenland inuit inuits permafrost Siberia |
op_source |
Rasmussen , M , Li , Y , Lindgreen , S , Pedersen , J S , Albrechtsen , A , Moltke , I , Metspalu , M , Metspalu , E , Kivisild , T , Gupta , R , Bertalan , M , Nielsen , K , Gilbert , T , Wang , Y , Raghavan , M , Campos , P , Kamp , H L M , Wilson , A S , Gledhill , A , Tridico , S , Bunce , M , Lorenzen , E , Binladen , J K M A , Guo , X , Zhao , J , Zhang , X , Zhang , H , Li , Z , Chen , M , Orlando , L A A , Kristiansen , K , Bak , M , Tommerup , N , Bendixen , C , Pierre , T L , Grønnow , B , Meldgaard , M , Andreasen , C , Fedorova , S A , Osipova , L P , Higham , T F G , Ramsey , C B , Hansen , T V O , Nielsen , F C , Crawford , M H , Brunak , S , Sicheritz-Pontén , T , Villems , R , Nielsen , R , Krogh , A , Wang , J & Willerslev , E 2010 , ' Ancient human genome sequence of an extinct Palaeo-Eskimo ' , Nature , vol. 463 , no. 7282 , pp. 757-762 . https://doi.org/10.1038/nature08835 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/nature08835 |
container_title |
Nature |
container_volume |
463 |
container_issue |
7282 |
container_start_page |
757 |
op_container_end_page |
762 |
_version_ |
1796308870554976256 |