Mutation of KRAS in colorectal adenocarcinoma in Greenland
KRAS mutation is one of the most frequent driver mutations in colorectal cancer (CRC) and is also a prognostic biomarker. The aim of the present study was to determine the frequency of KRAS mutations over time in the Greenlandic population diagnosed with CRC. In total, 578 patients with the diagnosi...
Published in: | APMIS |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2022
|
Subjects: | |
Online Access: | https://curis.ku.dk/portal/da/publications/mutation-of-kras-in-colorectal-adenocarcinoma-in-greenland(0bd60c8c-f32d-47bf-9e3e-fd20e181913a).html https://doi.org/10.1111/apm.13254 https://curis.ku.dk/ws/files/329417639/IKM_APMIS_2022_Mousavi_Mutation_of_KRAS_in_colorectal_adenocarcinoma_in_Greenland.pdf |
id |
ftcopenhagenunip:oai:pure.atira.dk:publications/0bd60c8c-f32d-47bf-9e3e-fd20e181913a |
---|---|
record_format |
openpolar |
spelling |
ftcopenhagenunip:oai:pure.atira.dk:publications/0bd60c8c-f32d-47bf-9e3e-fd20e181913a 2024-06-09T07:46:18+00:00 Mutation of KRAS in colorectal adenocarcinoma in Greenland Mousavi, Nabi Truelsen, Sarah Line Bring Bernth-Andersen, Simon Koch, Anders Heegaard, Steffen 2022 application/pdf https://curis.ku.dk/portal/da/publications/mutation-of-kras-in-colorectal-adenocarcinoma-in-greenland(0bd60c8c-f32d-47bf-9e3e-fd20e181913a).html https://doi.org/10.1111/apm.13254 https://curis.ku.dk/ws/files/329417639/IKM_APMIS_2022_Mousavi_Mutation_of_KRAS_in_colorectal_adenocarcinoma_in_Greenland.pdf eng eng info:eu-repo/semantics/openAccess Mousavi , N , Truelsen , S L B , Bernth-Andersen , S , Koch , A & Heegaard , S 2022 , ' Mutation of KRAS in colorectal adenocarcinoma in Greenland ' , APMIS , vol. 130 , no. 8 , pp. 493-497 . https://doi.org/10.1111/apm.13254 Colorectal cancer greenland inuit KRAS mutation population genetics article 2022 ftcopenhagenunip https://doi.org/10.1111/apm.13254 2024-05-16T11:29:26Z KRAS mutation is one of the most frequent driver mutations in colorectal cancer (CRC) and is also a prognostic biomarker. The aim of the present study was to determine the frequency of KRAS mutations over time in the Greenlandic population diagnosed with CRC. In total, 578 patients with the diagnosis of adenocarcinoma between 1988 and 2017 were identified. The status of KRAS and the mutational subtypes of KRAS mutations were determined in 102 representative samples by the Idylla™ platform in the time periods 1988–1990, 2002–2004, and 2015–2017. The results showed that the frequency of the KRAS mutations increased significantly, from 27% in 1988–1990 to 43% in 2015–2017 (p < 0.001). Furthermore, the most frequent subtypes of KRAS mutations in Greenland were G12D (c.35G > A) with 14%, G12V (c.35G > T) with 7%, and G13D (c.38G > A) with 6%. In conclusion, this study showed that the frequency of KRAS mutations in CRC has been increasing in recent decades in the specific population of Greenland. The results of this study may be used in initiatives related to targeted therapy of CRC in specific ethnicities and in investigations focusing on the environmental factors of cancer-related somatic mutations. Article in Journal/Newspaper Greenland greenlandic inuit University of Copenhagen: Research Greenland APMIS 130 8 493 497 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Colorectal cancer greenland inuit KRAS mutation population genetics |
spellingShingle |
Colorectal cancer greenland inuit KRAS mutation population genetics Mousavi, Nabi Truelsen, Sarah Line Bring Bernth-Andersen, Simon Koch, Anders Heegaard, Steffen Mutation of KRAS in colorectal adenocarcinoma in Greenland |
topic_facet |
Colorectal cancer greenland inuit KRAS mutation population genetics |
description |
KRAS mutation is one of the most frequent driver mutations in colorectal cancer (CRC) and is also a prognostic biomarker. The aim of the present study was to determine the frequency of KRAS mutations over time in the Greenlandic population diagnosed with CRC. In total, 578 patients with the diagnosis of adenocarcinoma between 1988 and 2017 were identified. The status of KRAS and the mutational subtypes of KRAS mutations were determined in 102 representative samples by the Idylla™ platform in the time periods 1988–1990, 2002–2004, and 2015–2017. The results showed that the frequency of the KRAS mutations increased significantly, from 27% in 1988–1990 to 43% in 2015–2017 (p < 0.001). Furthermore, the most frequent subtypes of KRAS mutations in Greenland were G12D (c.35G > A) with 14%, G12V (c.35G > T) with 7%, and G13D (c.38G > A) with 6%. In conclusion, this study showed that the frequency of KRAS mutations in CRC has been increasing in recent decades in the specific population of Greenland. The results of this study may be used in initiatives related to targeted therapy of CRC in specific ethnicities and in investigations focusing on the environmental factors of cancer-related somatic mutations. |
format |
Article in Journal/Newspaper |
author |
Mousavi, Nabi Truelsen, Sarah Line Bring Bernth-Andersen, Simon Koch, Anders Heegaard, Steffen |
author_facet |
Mousavi, Nabi Truelsen, Sarah Line Bring Bernth-Andersen, Simon Koch, Anders Heegaard, Steffen |
author_sort |
Mousavi, Nabi |
title |
Mutation of KRAS in colorectal adenocarcinoma in Greenland |
title_short |
Mutation of KRAS in colorectal adenocarcinoma in Greenland |
title_full |
Mutation of KRAS in colorectal adenocarcinoma in Greenland |
title_fullStr |
Mutation of KRAS in colorectal adenocarcinoma in Greenland |
title_full_unstemmed |
Mutation of KRAS in colorectal adenocarcinoma in Greenland |
title_sort |
mutation of kras in colorectal adenocarcinoma in greenland |
publishDate |
2022 |
url |
https://curis.ku.dk/portal/da/publications/mutation-of-kras-in-colorectal-adenocarcinoma-in-greenland(0bd60c8c-f32d-47bf-9e3e-fd20e181913a).html https://doi.org/10.1111/apm.13254 https://curis.ku.dk/ws/files/329417639/IKM_APMIS_2022_Mousavi_Mutation_of_KRAS_in_colorectal_adenocarcinoma_in_Greenland.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlandic inuit |
genre_facet |
Greenland greenlandic inuit |
op_source |
Mousavi , N , Truelsen , S L B , Bernth-Andersen , S , Koch , A & Heegaard , S 2022 , ' Mutation of KRAS in colorectal adenocarcinoma in Greenland ' , APMIS , vol. 130 , no. 8 , pp. 493-497 . https://doi.org/10.1111/apm.13254 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1111/apm.13254 |
container_title |
APMIS |
container_volume |
130 |
container_issue |
8 |
container_start_page |
493 |
op_container_end_page |
497 |
_version_ |
1801376096822755328 |