Archaic adaptive introgression in TBX15 / WARS2
A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using SNP chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to t...
Published in: | Molecular Biology and Evolution |
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2017
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Online Access: | https://curis.ku.dk/portal/da/publications/archaic-adaptive-introgression-in-tbx15wars2(026fdef1-0f79-4d85-9a3b-adf228acc3c6).html https://doi.org/10.1093/molbev/msw283 https://curis.ku.dk/ws/files/176658489/Racimo_2017_Archaic_adaptive.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/026fdef1-0f79-4d85-9a3b-adf228acc3c6 2024-05-12T08:04:25+00:00 Archaic adaptive introgression in TBX15 / WARS2 Racimo, Fernando Gokhman, David Fumagalli, Matteo Ko, Amy Hansen, Torben Moltke, Ida Albrechtsen, Anders Carmel, Liran Huerta-Sánchez, Emilia Nielsen, Rasmus 2017 application/pdf https://curis.ku.dk/portal/da/publications/archaic-adaptive-introgression-in-tbx15wars2(026fdef1-0f79-4d85-9a3b-adf228acc3c6).html https://doi.org/10.1093/molbev/msw283 https://curis.ku.dk/ws/files/176658489/Racimo_2017_Archaic_adaptive.pdf eng eng info:eu-repo/semantics/openAccess Racimo , F , Gokhman , D , Fumagalli , M , Ko , A , Hansen , T , Moltke , I , Albrechtsen , A , Carmel , L , Huerta-Sánchez , E & Nielsen , R 2017 , ' Archaic adaptive introgression in TBX15 / WARS2 ' , Molecular Biology and Evolution , vol. 34 , no. 3 , msw283 , pp. 509-524 . https://doi.org/10.1093/molbev/msw283 article 2017 ftcopenhagenunip https://doi.org/10.1093/molbev/msw283 2024-04-18T00:28:13Z A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using SNP chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome, and was likely introgressed from an archaic population. The region contains two genes, WARS2 and TBX15, and has previously been associated with adipose tissue differentiation and body-fat distribution in humans. We show that the adaptively introgressed allele has been under selection in a much larger geographic region than just Greenland. Furthermore, it is associated with changes in expression of WARS2 and TBX15 in multiple tissues including the adrenal gland and subcutaneous adipose tissue, and with regional DNA methylation changes in TBX15. Article in Journal/Newspaper Greenland greenlandic inuit University of Copenhagen: Research Greenland Molecular Biology and Evolution msw283 |
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Open Polar |
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University of Copenhagen: Research |
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ftcopenhagenunip |
language |
English |
description |
A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using SNP chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome, and was likely introgressed from an archaic population. The region contains two genes, WARS2 and TBX15, and has previously been associated with adipose tissue differentiation and body-fat distribution in humans. We show that the adaptively introgressed allele has been under selection in a much larger geographic region than just Greenland. Furthermore, it is associated with changes in expression of WARS2 and TBX15 in multiple tissues including the adrenal gland and subcutaneous adipose tissue, and with regional DNA methylation changes in TBX15. |
format |
Article in Journal/Newspaper |
author |
Racimo, Fernando Gokhman, David Fumagalli, Matteo Ko, Amy Hansen, Torben Moltke, Ida Albrechtsen, Anders Carmel, Liran Huerta-Sánchez, Emilia Nielsen, Rasmus |
spellingShingle |
Racimo, Fernando Gokhman, David Fumagalli, Matteo Ko, Amy Hansen, Torben Moltke, Ida Albrechtsen, Anders Carmel, Liran Huerta-Sánchez, Emilia Nielsen, Rasmus Archaic adaptive introgression in TBX15 / WARS2 |
author_facet |
Racimo, Fernando Gokhman, David Fumagalli, Matteo Ko, Amy Hansen, Torben Moltke, Ida Albrechtsen, Anders Carmel, Liran Huerta-Sánchez, Emilia Nielsen, Rasmus |
author_sort |
Racimo, Fernando |
title |
Archaic adaptive introgression in TBX15 / WARS2 |
title_short |
Archaic adaptive introgression in TBX15 / WARS2 |
title_full |
Archaic adaptive introgression in TBX15 / WARS2 |
title_fullStr |
Archaic adaptive introgression in TBX15 / WARS2 |
title_full_unstemmed |
Archaic adaptive introgression in TBX15 / WARS2 |
title_sort |
archaic adaptive introgression in tbx15 / wars2 |
publishDate |
2017 |
url |
https://curis.ku.dk/portal/da/publications/archaic-adaptive-introgression-in-tbx15wars2(026fdef1-0f79-4d85-9a3b-adf228acc3c6).html https://doi.org/10.1093/molbev/msw283 https://curis.ku.dk/ws/files/176658489/Racimo_2017_Archaic_adaptive.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlandic inuit |
genre_facet |
Greenland greenlandic inuit |
op_source |
Racimo , F , Gokhman , D , Fumagalli , M , Ko , A , Hansen , T , Moltke , I , Albrechtsen , A , Carmel , L , Huerta-Sánchez , E & Nielsen , R 2017 , ' Archaic adaptive introgression in TBX15 / WARS2 ' , Molecular Biology and Evolution , vol. 34 , no. 3 , msw283 , pp. 509-524 . https://doi.org/10.1093/molbev/msw283 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1093/molbev/msw283 |
container_title |
Molecular Biology and Evolution |
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msw283 |
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