Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two...

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Published in:Journal of Natural Products
Main Authors: Maier, Marta Silvia, Roccatagliata, Alejandro J., Kuriss, Anabel, Seldes, Marta Alicia, Pujol, Carlos Alberto, Damonte, Elsa Beatriz
Format: Article in Journal/Newspaper
Language:English
Published: American Chemical Society
Subjects:
Antarctic
The Antarctic
Argentina
Alicia
Silvia
Antarc*
Online Access:http://hdl.handle.net/11336/98860
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spelling ftconicet:oai:ri.conicet.gov.ar:11336/98860 2023-10-09T21:46:28+02:00 Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei Maier, Marta Silvia Roccatagliata, Alejandro J. Kuriss, Anabel Seldes, Marta Alicia Pujol, Carlos Alberto Damonte, Elsa Beatriz application/pdf http://hdl.handle.net/11336/98860 eng eng American Chemical Society info:eu-repo/semantics/altIdentifier/doi/10.1021/np000584i info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/np000584i http://hdl.handle.net/11336/98860 Maier, Marta Silvia; Roccatagliata, Alejandro J.; Kuriss, Anabel; Seldes, Marta Alicia; Pujol, Carlos Alberto; et al.; Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei; American Chemical Society; Journal of Natural Products; 64; 6; 12-2001; 732-736 0163-3864 CONICET Digital CONICET info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion ftconicet https://doi.org/10.1021/np000584i 2023-09-24T19:14:24Z Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL. Fil: Maier, Marta Silvia. Fil: J Roccatagliata, Alejandro. Fil: Anabel Kuriss,. Fil: Marta Seldes, Alicia. Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Article in Journal/Newspaper Antarc* Antarctic CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) Antarctic The Antarctic Argentina Alicia ENVELOPE(-63.483,-63.483,-64.833,-64.833) Silvia ENVELOPE(-57.900,-57.900,-63.300,-63.300) Journal of Natural Products 64 6 732 736
institution Open Polar
collection CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas)
op_collection_id ftconicet
language English
description Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL. Fil: Maier, Marta Silvia. Fil: J Roccatagliata, Alejandro. Fil: Anabel Kuriss,. Fil: Marta Seldes, Alicia. Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
format Article in Journal/Newspaper
author Maier, Marta Silvia
Roccatagliata, Alejandro J.
Kuriss, Anabel
Seldes, Marta Alicia
Pujol, Carlos Alberto
Damonte, Elsa Beatriz
spellingShingle Maier, Marta Silvia
Roccatagliata, Alejandro J.
Kuriss, Anabel
Seldes, Marta Alicia
Pujol, Carlos Alberto
Damonte, Elsa Beatriz
Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
author_facet Maier, Marta Silvia
Roccatagliata, Alejandro J.
Kuriss, Anabel
Seldes, Marta Alicia
Pujol, Carlos Alberto
Damonte, Elsa Beatriz
author_sort Maier, Marta Silvia
title Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_short Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_full Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_fullStr Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_full_unstemmed Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
title_sort two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber staurocucumis liouvillei
publisher American Chemical Society
url http://hdl.handle.net/11336/98860
long_lat ENVELOPE(-63.483,-63.483,-64.833,-64.833)
ENVELOPE(-57.900,-57.900,-63.300,-63.300)
geographic Antarctic
The Antarctic
Argentina
Alicia
Silvia
geographic_facet Antarctic
The Antarctic
Argentina
Alicia
Silvia
genre Antarc*
Antarctic
genre_facet Antarc*
Antarctic
op_relation info:eu-repo/semantics/altIdentifier/doi/10.1021/np000584i
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/np000584i
http://hdl.handle.net/11336/98860
Maier, Marta Silvia; Roccatagliata, Alejandro J.; Kuriss, Anabel; Seldes, Marta Alicia; Pujol, Carlos Alberto; et al.; Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei; American Chemical Society; Journal of Natural Products; 64; 6; 12-2001; 732-736
0163-3864
CONICET Digital
CONICET
op_rights info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
op_doi https://doi.org/10.1021/np000584i
container_title Journal of Natural Products
container_volume 64
container_issue 6
container_start_page 732
op_container_end_page 736
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