Regioselective enzymatic synthesis of estradiol 17-fatty acid esters

• Main Authors: Rustoy, Eduardo Miguel, Ruiz Arias, Ignacio Edgardo, Baldessari, Alicia
• Format: Article in Journal/Newspaper
• Language: English
• Published: Arkat USA
• Subjects: Lipase; Enzymatic acilation and alcoholysis; 3,17- ß-estradiol; https://purl.org/becyt/ford/1.4; https://purl.org/becyt/ford/1; Argentina; Rugosa; Alicia; Edgardo; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/11336/92316

A series of acyl esters of 3,17-β-estradiol has been prepared by an enzymatic methodology. Eleven 17-monoacyl products (five novel compounds) were obtained in a highly regioselective way by acylation of 3,17-β-estradiol or by alcoholysis of the corresponding diacyl derivatives. The influence of vari...