Lipase-catalysed deacetylation of androstane and pregnane derivatives: Influence of ring D substitution

• Published in: Journal of Molecular Catalysis B: Enzymatic
• Main Authors: Bruttomesso, Andrea, Baldessari, Alicia
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier Science
• Subjects: ANDROSTANE; LIPASE-CATALYSED DEACETYLATION; PREGNANE; https://purl.org/becyt/ford/1.4; https://purl.org/becyt/ford/1; Argentina; Rugosa; Alicia; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/11336/84865

A series of acetoxy derivatives of androstane and pregnane was deacetylated in organic solvents by microbial lipases. The best results were obtained with lipase from Candida antarctica (CAL B), Candida rugosa (CRL) and Pseudomonas sp. (PSL). In some derivatives, CAL B and CRL showed a regioselective...