An efficient and mild access to N-acetyl protected purine nucleosides based on a chemoselective enzymatic hydrolysis

• Published in: Journal of Biotechnology
• Main Authors: Palacio, Cyntia M., Sabaini, María Belén, Iribarren, Adolfo Marcelo, Iglesias, Luis Emilio
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier
• Subjects: Chemoselectivity; Candida Antarctica Lipase B; Acylase I; Nucleobase N-Protection; Oligonucleotide Building Blocks; https://purl.org/becyt/ford/1.4; https://purl.org/becyt/ford/1; Argentina; Quilmes; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/11336/24092

N-Monoacetylated derivatives of ribo- (adenosine, guanosine) and 2′-deoxyribonucleosides (2′-deoxyadenosine and 2′-deoxyguanosine), useful as oligonucleotide building blocks, were obtained in 88–100% by enzymatic chemoselective hydrolysis of the corresponding peracetylated nucleosides. Among the tes...