A simple molecular model to study the substrate diffusion into the active site of a lipase-catalyzed esterification of ibuprofen and ketoprofen with glycerol

• Published in: Topics in Catalysis
• Main Authors: Toledo, Victoria, Briand, Laura Estefania, Ferreira, María Luján
• Format: Article in Journal/Newspaper
• Language: English
• Published: Springer/Plenum Publishers
• Subjects: CALB; GLYCEROL; MOLECULAR MODELLING; NSAIDS; https://purl.org/becyt/ford/2.9; https://purl.org/becyt/ford/2; Argentina; Toledo; Briand; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/11336/204043

Lipases are enzymes widely applied in the kinetic resolution of racemic non-steroidal anti-inflammatory drugs (NSAIDs). The esterification of racemic ibuprofen and ketoprofen with glycerol catalyzed by the lipase B of Candida antarctica (CALB) was performed by some of us, achieving very different re...