Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery
Nanotechnology for brain drug delivery comprises the promise for future possibilities of successful treatment in several central nervous system pathologies currently deficient in curative treatments, such as neurodegenerative disorders and malignant glioblastoma. Nevertheless, the neurotoxic effects...
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ftconicet:oai:ri.conicet.gov.ar:11336/143015 2023-10-09T21:53:24+02:00 Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery Catalan Figueroa, Johanna Francesca Morales Montecinos, Javier Octavio Morales Montecinos, Javier Octavio Gaillard, Pieter J. application/pdf http://hdl.handle.net/11336/143015 eng eng Humana Press info:eu-repo/semantics/altIdentifier/doi/10.1007/978-1-0716-0838-8_10 info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/protocol/10.1007%2F978-1-0716-0838-8_10 http://hdl.handle.net/11336/143015 Catalan Figueroa, Johanna Francesca; Morales Montecinos, Javier Octavio; Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery; Humana Press; 157; 2020; 255-277 978-1-07-160838-8 0893-2336 1940-6045 CONICET Digital CONICET info:eu-repo/semantics/restrictedAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ Neurotoxicity Neurodegeneration Nanoparticle toxicity Brain Autophagy Oxidative stress https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/bookPart info:ar-repo/semantics/parte de libro ftconicet https://doi.org/10.1007/978-1-0716-0838-8_10 2023-09-24T19:15:10Z Nanotechnology for brain drug delivery comprises the promise for future possibilities of successful treatment in several central nervous system pathologies currently deficient in curative treatments, such as neurodegenerative disorders and malignant glioblastoma. Nevertheless, the neurotoxic effects exerted by several types of nanomaterials are the same as those involved in the pathology of neurodegeneration; thus it is important to have a deep knowledge of these mechanisms so that a proper approach can be taken into consideration. On the other hand, cancer cells usually respond differently to normal cells, being this characteristic a potential advantage for brain cancer therapy. In this chapter we analyze the mechanisms behind neurotoxic effects, from a multidisciplinary perspective, aiming to highlight the disadvantages of nanomaterials for the development of brain-targeted nanocarriers. Fil: Catalan Figueroa, Johanna Francesca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad de Chile; Chile. Centro de Estudios Avanzados de Enfermedades Crónicas; Chile Fil: Morales Montecinos, Javier Octavio. Universidad de Chile; Chile. Centro de Estudios Avanzados de Enfermedades Crónicas; Chile. Luleå University of Technology; Suecia Book Part Luleå Luleå Luleå CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) Argentina Suecia ENVELOPE(-62.617,-62.617,-66.733,-66.733) Morales ENVELOPE(-55.833,-55.833,-63.000,-63.000) Figueroa ENVELOPE(-61.033,-61.033,-64.067,-64.067) Montecinos ENVELOPE(-59.684,-59.684,-62.500,-62.500) 255 277 |
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Open Polar |
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CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
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ftconicet |
language |
English |
topic |
Neurotoxicity Neurodegeneration Nanoparticle toxicity Brain Autophagy Oxidative stress https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
spellingShingle |
Neurotoxicity Neurodegeneration Nanoparticle toxicity Brain Autophagy Oxidative stress https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 Catalan Figueroa, Johanna Francesca Morales Montecinos, Javier Octavio Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery |
topic_facet |
Neurotoxicity Neurodegeneration Nanoparticle toxicity Brain Autophagy Oxidative stress https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
description |
Nanotechnology for brain drug delivery comprises the promise for future possibilities of successful treatment in several central nervous system pathologies currently deficient in curative treatments, such as neurodegenerative disorders and malignant glioblastoma. Nevertheless, the neurotoxic effects exerted by several types of nanomaterials are the same as those involved in the pathology of neurodegeneration; thus it is important to have a deep knowledge of these mechanisms so that a proper approach can be taken into consideration. On the other hand, cancer cells usually respond differently to normal cells, being this characteristic a potential advantage for brain cancer therapy. In this chapter we analyze the mechanisms behind neurotoxic effects, from a multidisciplinary perspective, aiming to highlight the disadvantages of nanomaterials for the development of brain-targeted nanocarriers. Fil: Catalan Figueroa, Johanna Francesca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad de Chile; Chile. Centro de Estudios Avanzados de Enfermedades Crónicas; Chile Fil: Morales Montecinos, Javier Octavio. Universidad de Chile; Chile. Centro de Estudios Avanzados de Enfermedades Crónicas; Chile. Luleå University of Technology; Suecia |
author2 |
Morales Montecinos, Javier Octavio Gaillard, Pieter J. |
format |
Book Part |
author |
Catalan Figueroa, Johanna Francesca Morales Montecinos, Javier Octavio |
author_facet |
Catalan Figueroa, Johanna Francesca Morales Montecinos, Javier Octavio |
author_sort |
Catalan Figueroa, Johanna Francesca |
title |
Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery |
title_short |
Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery |
title_full |
Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery |
title_fullStr |
Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery |
title_full_unstemmed |
Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery |
title_sort |
safety and nanotoxicity aspects of nanomedicines for brain-targeted drug delivery |
publisher |
Humana Press |
url |
http://hdl.handle.net/11336/143015 |
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ENVELOPE(-62.617,-62.617,-66.733,-66.733) ENVELOPE(-55.833,-55.833,-63.000,-63.000) ENVELOPE(-61.033,-61.033,-64.067,-64.067) ENVELOPE(-59.684,-59.684,-62.500,-62.500) |
geographic |
Argentina Suecia Morales Figueroa Montecinos |
geographic_facet |
Argentina Suecia Morales Figueroa Montecinos |
genre |
Luleå Luleå Luleå |
genre_facet |
Luleå Luleå Luleå |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1007/978-1-0716-0838-8_10 info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/protocol/10.1007%2F978-1-0716-0838-8_10 http://hdl.handle.net/11336/143015 Catalan Figueroa, Johanna Francesca; Morales Montecinos, Javier Octavio; Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery; Humana Press; 157; 2020; 255-277 978-1-07-160838-8 0893-2336 1940-6045 CONICET Digital CONICET |
op_rights |
info:eu-repo/semantics/restrictedAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
op_doi |
https://doi.org/10.1007/978-1-0716-0838-8_10 |
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255 |
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