Repositioning of the global epicentre of non-optimal cholesterol
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct...
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ftconicet:oai:ri.conicet.gov.ar:11336/142685 2023-10-09T21:52:04+02:00 Repositioning of the global epicentre of non-optimal cholesterol Irazola, Vilma Rubinstein, Adolfo Luis Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K Di Cesare, Mariachiara Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Elías Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young Ho Kuulasmaa, Kari Laxmaiah, Avula application/pdf http://hdl.handle.net/11336/142685 eng eng Nature Publishing Group info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41586-020-2338-1 info:eu-repo/semantics/altIdentifier/doi/10.1038/s41586-020-2338-1 http://hdl.handle.net/11336/142685 Irazola, Vilma; Rubinstein, Adolfo Luis; Taddei, Cristina; Zhou, Bin; Bixby, Honor; et al.; Repositioning of the global epicentre of non-optimal cholesterol; Nature Publishing Group; Nature; 582; 7810; 6-2020; 73-77 0028-0836 CONICET Digital CONICET info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ Repositioning epicentre non-optimal cholesterol https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion ftconicet https://doi.org/10.1038/s41586-020-2338-1 2023-09-24T18:30:39Z High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment ... Article in Journal/Newspaper Greenland Iceland CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) Greenland Pacific Norway Nature 582 7810 73 77 |
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Repositioning epicentre non-optimal cholesterol https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
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Repositioning epicentre non-optimal cholesterol https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 Irazola, Vilma Rubinstein, Adolfo Luis Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K Di Cesare, Mariachiara Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Elías Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young Ho Kuulasmaa, Kari Laxmaiah, Avula Repositioning of the global epicentre of non-optimal cholesterol |
topic_facet |
Repositioning epicentre non-optimal cholesterol https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
description |
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment ... |
format |
Article in Journal/Newspaper |
author |
Irazola, Vilma Rubinstein, Adolfo Luis Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K Di Cesare, Mariachiara Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Elías Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young Ho Kuulasmaa, Kari Laxmaiah, Avula |
author_facet |
Irazola, Vilma Rubinstein, Adolfo Luis Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K Di Cesare, Mariachiara Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Elías Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young Ho Kuulasmaa, Kari Laxmaiah, Avula |
author_sort |
Irazola, Vilma |
title |
Repositioning of the global epicentre of non-optimal cholesterol |
title_short |
Repositioning of the global epicentre of non-optimal cholesterol |
title_full |
Repositioning of the global epicentre of non-optimal cholesterol |
title_fullStr |
Repositioning of the global epicentre of non-optimal cholesterol |
title_full_unstemmed |
Repositioning of the global epicentre of non-optimal cholesterol |
title_sort |
repositioning of the global epicentre of non-optimal cholesterol |
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Nature Publishing Group |
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http://hdl.handle.net/11336/142685 |
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info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41586-020-2338-1 info:eu-repo/semantics/altIdentifier/doi/10.1038/s41586-020-2338-1 http://hdl.handle.net/11336/142685 Irazola, Vilma; Rubinstein, Adolfo Luis; Taddei, Cristina; Zhou, Bin; Bixby, Honor; et al.; Repositioning of the global epicentre of non-optimal cholesterol; Nature Publishing Group; Nature; 582; 7810; 6-2020; 73-77 0028-0836 CONICET Digital CONICET |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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https://doi.org/10.1038/s41586-020-2338-1 |
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Nature |
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