Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, l...
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ftconicet:oai:ri.conicet.gov.ar:11336/141119 2023-10-09T21:47:14+02:00 Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird Levy, Hila Fiddaman, Steven R. Vianna, Juliana A. Noll, Daly Clucas, Gemma V. Sidhu, Jasmine K.H. Polito, Michael J. Bost, Charles A. Phillips, Richard A. Crofts, Sarah Miller, Gary D. Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Celine Barbosa, Andres Trathan, Phil Raya Rey, Andrea Nélida Frantz, Laurent A.F. Hart, Tom Smith, Adrian L. application/pdf http://hdl.handle.net/11336/141119 eng eng Oxford University Press info:eu-repo/semantics/altIdentifier/doi/10.1093/molbev/msaa040 info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/mbe/article/37/6/1708/5756218 http://hdl.handle.net/11336/141119 Levy, Hila; Fiddaman, Steven R.; Vianna, Juliana A.; Noll, Daly; Clucas, Gemma V.; et al.; Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird; Oxford University Press; Molecular Biology and Evolution; 37; 6; 2-2020; 1708-1726 0737-4038 CONICET Digital CONICET info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ ANTARCTICA AND SOUTHERN OCEAN GENTOO PENGUIN IMMUNOGENETICS PATHOGEN-MEDIATED SELECTION POSITIVE SELECTION TOLL-LIKE RECEPTORS https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion ftconicet https://doi.org/10.1093/molbev/msaa040 2023-09-24T19:54:48Z Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation becauseof its circumpolardistributionover a large latitudinal range, with littleornoadmixturebetweendifferent clades. Inthis study,we examine thediversity ina key family of innateimmunegenes-theToll-like receptors (TLRs)-across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7.We present evidence of positive selection in TLR4 and TLR5,which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world's most rapidly changing environments. Fil: Levy, Hila. University of Oxford; Reino Unido Fil: Fiddaman, Steven R. University of Oxford; Reino Unido Fil: Vianna, Juliana A. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Noll, Daly. Pontificia Universidad Católica de Chile; Chile. Universidad de Chile; Chile Fil: Clucas, Gemma V. Cornell University; Estados Unidos Fil: Sidhu, Jasmine K.H. University of Oxford; Reino Unido Fil: Polito, Michael J. Louisiana State University; Estados Unidos Fil: Bost, Charles A. Centre D'etudes Biologiques de ... Article in Journal/Newspaper Antarc* Antarctica Gentoo penguin Pygoscelis papua Southern Ocean CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) Southern Ocean Levy ENVELOPE(-66.567,-66.567,-66.320,-66.320) Daly ENVELOPE(63.761,63.761,-67.513,-67.513) Molecular Biology and Evolution 37 6 1708 1726 |
institution |
Open Polar |
collection |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
op_collection_id |
ftconicet |
language |
English |
topic |
ANTARCTICA AND SOUTHERN OCEAN GENTOO PENGUIN IMMUNOGENETICS PATHOGEN-MEDIATED SELECTION POSITIVE SELECTION TOLL-LIKE RECEPTORS https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
spellingShingle |
ANTARCTICA AND SOUTHERN OCEAN GENTOO PENGUIN IMMUNOGENETICS PATHOGEN-MEDIATED SELECTION POSITIVE SELECTION TOLL-LIKE RECEPTORS https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 Levy, Hila Fiddaman, Steven R. Vianna, Juliana A. Noll, Daly Clucas, Gemma V. Sidhu, Jasmine K.H. Polito, Michael J. Bost, Charles A. Phillips, Richard A. Crofts, Sarah Miller, Gary D. Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Celine Barbosa, Andres Trathan, Phil Raya Rey, Andrea Nélida Frantz, Laurent A.F. Hart, Tom Smith, Adrian L. Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
topic_facet |
ANTARCTICA AND SOUTHERN OCEAN GENTOO PENGUIN IMMUNOGENETICS PATHOGEN-MEDIATED SELECTION POSITIVE SELECTION TOLL-LIKE RECEPTORS https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
description |
Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation becauseof its circumpolardistributionover a large latitudinal range, with littleornoadmixturebetweendifferent clades. Inthis study,we examine thediversity ina key family of innateimmunegenes-theToll-like receptors (TLRs)-across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7.We present evidence of positive selection in TLR4 and TLR5,which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world's most rapidly changing environments. Fil: Levy, Hila. University of Oxford; Reino Unido Fil: Fiddaman, Steven R. University of Oxford; Reino Unido Fil: Vianna, Juliana A. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Noll, Daly. Pontificia Universidad Católica de Chile; Chile. Universidad de Chile; Chile Fil: Clucas, Gemma V. Cornell University; Estados Unidos Fil: Sidhu, Jasmine K.H. University of Oxford; Reino Unido Fil: Polito, Michael J. Louisiana State University; Estados Unidos Fil: Bost, Charles A. Centre D'etudes Biologiques de ... |
format |
Article in Journal/Newspaper |
author |
Levy, Hila Fiddaman, Steven R. Vianna, Juliana A. Noll, Daly Clucas, Gemma V. Sidhu, Jasmine K.H. Polito, Michael J. Bost, Charles A. Phillips, Richard A. Crofts, Sarah Miller, Gary D. Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Celine Barbosa, Andres Trathan, Phil Raya Rey, Andrea Nélida Frantz, Laurent A.F. Hart, Tom Smith, Adrian L. |
author_facet |
Levy, Hila Fiddaman, Steven R. Vianna, Juliana A. Noll, Daly Clucas, Gemma V. Sidhu, Jasmine K.H. Polito, Michael J. Bost, Charles A. Phillips, Richard A. Crofts, Sarah Miller, Gary D. Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Celine Barbosa, Andres Trathan, Phil Raya Rey, Andrea Nélida Frantz, Laurent A.F. Hart, Tom Smith, Adrian L. |
author_sort |
Levy, Hila |
title |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_short |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_full |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_fullStr |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_full_unstemmed |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_sort |
evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
publisher |
Oxford University Press |
url |
http://hdl.handle.net/11336/141119 |
long_lat |
ENVELOPE(-66.567,-66.567,-66.320,-66.320) ENVELOPE(63.761,63.761,-67.513,-67.513) |
geographic |
Southern Ocean Levy Daly |
geographic_facet |
Southern Ocean Levy Daly |
genre |
Antarc* Antarctica Gentoo penguin Pygoscelis papua Southern Ocean |
genre_facet |
Antarc* Antarctica Gentoo penguin Pygoscelis papua Southern Ocean |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1093/molbev/msaa040 info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/mbe/article/37/6/1708/5756218 http://hdl.handle.net/11336/141119 Levy, Hila; Fiddaman, Steven R.; Vianna, Juliana A.; Noll, Daly; Clucas, Gemma V.; et al.; Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird; Oxford University Press; Molecular Biology and Evolution; 37; 6; 2-2020; 1708-1726 0737-4038 CONICET Digital CONICET |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
op_doi |
https://doi.org/10.1093/molbev/msaa040 |
container_title |
Molecular Biology and Evolution |
container_volume |
37 |
container_issue |
6 |
container_start_page |
1708 |
op_container_end_page |
1726 |
_version_ |
1779310196444626944 |