Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
Endosulfan (ES), a persistent organochlorine pesticide, is widely used worldwide despite its toxicity to non-target animals. Upon reaching water bodies, ES can cause negative effects on aquatic animals, including disruption of hormonal systems. However, the action of ES on fish reproductive axis has...
Published in: | Aquatic Toxicology |
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Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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Elsevier Science
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Online Access: | http://hdl.handle.net/11336/12679 |
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CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
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English |
topic |
endosulfan cichlid fish endocrine disruption testes pathology gonadotropins sex steroids Otras Ciencias Biológicas Ciencias Biológicas CIENCIAS NATURALES Y EXACTAS |
spellingShingle |
endosulfan cichlid fish endocrine disruption testes pathology gonadotropins sex steroids Otras Ciencias Biológicas Ciencias Biológicas CIENCIAS NATURALES Y EXACTAS Da Cuña, Rodrigo Hernán Pandolfi, Matias Genovese, Griselda Piazza, Yanina Grisel Ansaldo, Martín Lo Nostro, Fabiana Laura Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae) |
topic_facet |
endosulfan cichlid fish endocrine disruption testes pathology gonadotropins sex steroids Otras Ciencias Biológicas Ciencias Biológicas CIENCIAS NATURALES Y EXACTAS |
description |
Endosulfan (ES), a persistent organochlorine pesticide, is widely used worldwide despite its toxicity to non-target animals. Upon reaching water bodies, ES can cause negative effects on aquatic animals, including disruption of hormonal systems. However, the action of ES on fish reproductive axis has been hardly studied thus far. The aim of the present work was to analyze the endocrine disruptive potential of endosulfan on the pituitary gonadotropins levels and on the testes function due to ES in the South American freshwater fish Cichlasoma dimerus, using in vivo and in vitro approaches. Waterborne ES (0.1, 0.3 and 1 g/L) exposure for two months caused decrease in FSH pituitary content and GT activity in the testes (Sertoli cell function marker). Testicular alterations such as scarce intermediate stages of spermatogenesis, release of immature germ cells into the lobular lumen, presence of foam cells and interstitial fibrosis, were also observed. In vitro experiments showed that ES inhibited the LH-stimulated steroidogenesis in gonads. As FSH and FSH-mediated steroidogenesis regulate spermatogenesis and Sertoli cell function, the effect of ES on FSH could be responsible for the morphological alterations observed in testes. Direct effects can also be occurring through disruption of steroidogenesis, as observed in vitro. Based on this evidence, ES exhibits an endocrine disruptive action on the reproductive axis of C. dimerus, causing disruption at the pituitary and/or at the gonad level. These effects could acquire greater significance under prolonged exposure to the pesticide in nature. Fil: Da Cuña, Rodrigo Hernán. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pandolfi, Matias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología y Comportamiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Genovese, Griselda. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Piazza, Yanina Grisel. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ansaldo, Martín. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; Argentina Fil: Lo Nostro, Fabiana Laura. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
format |
Article in Journal/Newspaper |
author |
Da Cuña, Rodrigo Hernán Pandolfi, Matias Genovese, Griselda Piazza, Yanina Grisel Ansaldo, Martín Lo Nostro, Fabiana Laura |
author_facet |
Da Cuña, Rodrigo Hernán Pandolfi, Matias Genovese, Griselda Piazza, Yanina Grisel Ansaldo, Martín Lo Nostro, Fabiana Laura |
author_sort |
Da Cuña, Rodrigo Hernán |
title |
Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae) |
title_short |
Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae) |
title_full |
Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae) |
title_fullStr |
Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae) |
title_full_unstemmed |
Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae) |
title_sort |
endocrine disruptive potential of endosulfan on the reproductive axis of c. dimerus (perciformes, cichlidae) |
publisher |
Elsevier Science |
url |
http://hdl.handle.net/11336/12679 |
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ENVELOPE(-62.867,-62.867,-64.900,-64.900) |
geographic |
Argentina Argentino Hernán |
geographic_facet |
Argentina Argentino Hernán |
genre |
Dirección Nacional del Antártico Instituto Antártico Argentino |
genre_facet |
Dirección Nacional del Antártico Instituto Antártico Argentino |
op_relation |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166445X12002767 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aquatox.2012.09.015 Da Cuña, Rodrigo Hernán; Pandolfi, Matias; Genovese, Griselda; Piazza, Yanina Grisel; Ansaldo, Martín; et al.; Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae); Elsevier Science; Aquatic Toxicology; 126; 1-2013; 299-305 0166-445X http://hdl.handle.net/11336/12679 |
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info:eu-repo/semantics/restrictedAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
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CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.aquatox.2012.09.015 |
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Aquatic Toxicology |
container_volume |
126 |
container_start_page |
299 |
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spelling |
ftconicet:oai:ri.conicet.gov.ar:11336/12679 2023-05-15T16:01:01+02:00 Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae) Da Cuña, Rodrigo Hernán Pandolfi, Matias Genovese, Griselda Piazza, Yanina Grisel Ansaldo, Martín Lo Nostro, Fabiana Laura application/pdf http://hdl.handle.net/11336/12679 eng eng Elsevier Science info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166445X12002767 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aquatox.2012.09.015 Da Cuña, Rodrigo Hernán; Pandolfi, Matias; Genovese, Griselda; Piazza, Yanina Grisel; Ansaldo, Martín; et al.; Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae); Elsevier Science; Aquatic Toxicology; 126; 1-2013; 299-305 0166-445X http://hdl.handle.net/11336/12679 info:eu-repo/semantics/restrictedAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ CC-BY-NC-ND endosulfan cichlid fish endocrine disruption testes pathology gonadotropins sex steroids Otras Ciencias Biológicas Ciencias Biológicas CIENCIAS NATURALES Y EXACTAS info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion ftconicet https://doi.org/10.1016/j.aquatox.2012.09.015 2019-08-31T17:07:59Z Endosulfan (ES), a persistent organochlorine pesticide, is widely used worldwide despite its toxicity to non-target animals. Upon reaching water bodies, ES can cause negative effects on aquatic animals, including disruption of hormonal systems. However, the action of ES on fish reproductive axis has been hardly studied thus far. The aim of the present work was to analyze the endocrine disruptive potential of endosulfan on the pituitary gonadotropins levels and on the testes function due to ES in the South American freshwater fish Cichlasoma dimerus, using in vivo and in vitro approaches. Waterborne ES (0.1, 0.3 and 1 g/L) exposure for two months caused decrease in FSH pituitary content and GT activity in the testes (Sertoli cell function marker). Testicular alterations such as scarce intermediate stages of spermatogenesis, release of immature germ cells into the lobular lumen, presence of foam cells and interstitial fibrosis, were also observed. In vitro experiments showed that ES inhibited the LH-stimulated steroidogenesis in gonads. As FSH and FSH-mediated steroidogenesis regulate spermatogenesis and Sertoli cell function, the effect of ES on FSH could be responsible for the morphological alterations observed in testes. Direct effects can also be occurring through disruption of steroidogenesis, as observed in vitro. Based on this evidence, ES exhibits an endocrine disruptive action on the reproductive axis of C. dimerus, causing disruption at the pituitary and/or at the gonad level. These effects could acquire greater significance under prolonged exposure to the pesticide in nature. Fil: Da Cuña, Rodrigo Hernán. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pandolfi, Matias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología y Comportamiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Genovese, Griselda. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Piazza, Yanina Grisel. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ansaldo, Martín. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; Argentina Fil: Lo Nostro, Fabiana Laura. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Article in Journal/Newspaper Dirección Nacional del Antártico Instituto Antártico Argentino CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) Argentina Argentino Hernán ENVELOPE(-62.867,-62.867,-64.900,-64.900) Aquatic Toxicology 126 299 305 |