The Genetic History of Native Americans
The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved1, 2, 3, 4, 5. One contentious issue is whether the settlement occurred by means of a single6, 7, 8 migration or multiple streams of migration f...
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ftconicet:oai:ri.conicet.gov.ar:11336/125482 2023-10-09T21:44:20+02:00 The Genetic History of Native Americans Reich, David Patterson, Nick Campbell, Desmond Tandon, Arti Mazieres, Stéphane Ray, Nicolas Parra, Maria V. Rojas, Winston Duque, Constanza Mesa, Natalia García, Luis F. Triana, Omar Blair, Silvia Maestre, Amanda Dib, Juan C. Bravi, Claudio Marcelo Bailliet, Graciela Corach, Daniel Hünemeier, Tábita Bortolini, Maria Cátira Salzano, Francisco M. Petzl Erler, María Luiza Acuña Alonzo, Victor Aguilar-Salinas, Carlos Canizales Quinteros, Samuel Tusié Luna, Teresa Riba, Laura Rodríguez Cruz, Maricela Lopez Alarcón, Mardia Coral Vazquez, Ramón application/pdf http://hdl.handle.net/11336/125482 eng eng Nature Publishing Group info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11258.html info:eu-repo/semantics/altIdentifier/doi/10.1038/nature11258 http://hdl.handle.net/11336/125482 Reich, David; Patterson, Nick; Campbell, Desmond; Tandon, Arti; Mazieres, Stéphane; et al.; The Genetic History of Native Americans; Nature Publishing Group; Nature; 488; 7411; 8-2012; 370-374 0028-0836 CONICET Digital CONICET info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ Native Americans Peopling of America Genomics South America North America https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/6.5 https://purl.org/becyt/ford/6 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion ftconicet https://doi.org/10.1038/nature11258 2023-09-24T20:02:14Z The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved1, 2, 3, 4, 5. One contentious issue is whether the settlement occurred by means of a single6, 7, 8 migration or multiple streams of migration from Siberia9, 10, 11, 12, 13, 14, 15. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call ?First American?. However, speakers of Eskimo?Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America. Fil: Reich, David. Harvard Medical School; Estados Unidos Fil: Patterson, Nick. Massachusetts Institute of Technology; Estados Unidos Fil: Campbell, Desmond. Dept Genet, Evol & Environment, Univ. College London; Reino Unido Fil: Tandon, Arti. Harvard Medical School; Estados Unidos Fil: Mazieres, Stéphane. Dept Genet, Evol & Environment, Univ. College London; Reino Unido. Aix-marseille Université/cnrs/efs; Francia Fil: Ray, Nicolas. University Of Geneva; Suiza Fil: Parra, Maria V. Colegio Universitario de Londres. Department Of Genetics, Evolution And Enviroment; Reino Unido. Universidad de Antioquia, Medellín, Colombia; Colombia Fil: Rojas, Winston. ... Article in Journal/Newspaper aleut Arctic Chipewyan eskimo* Eskimo–Aleut CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) Arctic Canada Rojas ENVELOPE(-63.950,-63.950,-64.817,-64.817) Nature 488 7411 370 374 |
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CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
op_collection_id |
ftconicet |
language |
English |
topic |
Native Americans Peopling of America Genomics South America North America https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/6.5 https://purl.org/becyt/ford/6 |
spellingShingle |
Native Americans Peopling of America Genomics South America North America https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/6.5 https://purl.org/becyt/ford/6 Reich, David Patterson, Nick Campbell, Desmond Tandon, Arti Mazieres, Stéphane Ray, Nicolas Parra, Maria V. Rojas, Winston Duque, Constanza Mesa, Natalia García, Luis F. Triana, Omar Blair, Silvia Maestre, Amanda Dib, Juan C. Bravi, Claudio Marcelo Bailliet, Graciela Corach, Daniel Hünemeier, Tábita Bortolini, Maria Cátira Salzano, Francisco M. Petzl Erler, María Luiza Acuña Alonzo, Victor Aguilar-Salinas, Carlos Canizales Quinteros, Samuel Tusié Luna, Teresa Riba, Laura Rodríguez Cruz, Maricela Lopez Alarcón, Mardia Coral Vazquez, Ramón The Genetic History of Native Americans |
topic_facet |
Native Americans Peopling of America Genomics South America North America https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/6.5 https://purl.org/becyt/ford/6 |
description |
The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved1, 2, 3, 4, 5. One contentious issue is whether the settlement occurred by means of a single6, 7, 8 migration or multiple streams of migration from Siberia9, 10, 11, 12, 13, 14, 15. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call ?First American?. However, speakers of Eskimo?Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America. Fil: Reich, David. Harvard Medical School; Estados Unidos Fil: Patterson, Nick. Massachusetts Institute of Technology; Estados Unidos Fil: Campbell, Desmond. Dept Genet, Evol & Environment, Univ. College London; Reino Unido Fil: Tandon, Arti. Harvard Medical School; Estados Unidos Fil: Mazieres, Stéphane. Dept Genet, Evol & Environment, Univ. College London; Reino Unido. Aix-marseille Université/cnrs/efs; Francia Fil: Ray, Nicolas. University Of Geneva; Suiza Fil: Parra, Maria V. Colegio Universitario de Londres. Department Of Genetics, Evolution And Enviroment; Reino Unido. Universidad de Antioquia, Medellín, Colombia; Colombia Fil: Rojas, Winston. ... |
format |
Article in Journal/Newspaper |
author |
Reich, David Patterson, Nick Campbell, Desmond Tandon, Arti Mazieres, Stéphane Ray, Nicolas Parra, Maria V. Rojas, Winston Duque, Constanza Mesa, Natalia García, Luis F. Triana, Omar Blair, Silvia Maestre, Amanda Dib, Juan C. Bravi, Claudio Marcelo Bailliet, Graciela Corach, Daniel Hünemeier, Tábita Bortolini, Maria Cátira Salzano, Francisco M. Petzl Erler, María Luiza Acuña Alonzo, Victor Aguilar-Salinas, Carlos Canizales Quinteros, Samuel Tusié Luna, Teresa Riba, Laura Rodríguez Cruz, Maricela Lopez Alarcón, Mardia Coral Vazquez, Ramón |
author_facet |
Reich, David Patterson, Nick Campbell, Desmond Tandon, Arti Mazieres, Stéphane Ray, Nicolas Parra, Maria V. Rojas, Winston Duque, Constanza Mesa, Natalia García, Luis F. Triana, Omar Blair, Silvia Maestre, Amanda Dib, Juan C. Bravi, Claudio Marcelo Bailliet, Graciela Corach, Daniel Hünemeier, Tábita Bortolini, Maria Cátira Salzano, Francisco M. Petzl Erler, María Luiza Acuña Alonzo, Victor Aguilar-Salinas, Carlos Canizales Quinteros, Samuel Tusié Luna, Teresa Riba, Laura Rodríguez Cruz, Maricela Lopez Alarcón, Mardia Coral Vazquez, Ramón |
author_sort |
Reich, David |
title |
The Genetic History of Native Americans |
title_short |
The Genetic History of Native Americans |
title_full |
The Genetic History of Native Americans |
title_fullStr |
The Genetic History of Native Americans |
title_full_unstemmed |
The Genetic History of Native Americans |
title_sort |
genetic history of native americans |
publisher |
Nature Publishing Group |
url |
http://hdl.handle.net/11336/125482 |
long_lat |
ENVELOPE(-63.950,-63.950,-64.817,-64.817) |
geographic |
Arctic Canada Rojas |
geographic_facet |
Arctic Canada Rojas |
genre |
aleut Arctic Chipewyan eskimo* Eskimo–Aleut |
genre_facet |
aleut Arctic Chipewyan eskimo* Eskimo–Aleut |
op_relation |
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11258.html info:eu-repo/semantics/altIdentifier/doi/10.1038/nature11258 http://hdl.handle.net/11336/125482 Reich, David; Patterson, Nick; Campbell, Desmond; Tandon, Arti; Mazieres, Stéphane; et al.; The Genetic History of Native Americans; Nature Publishing Group; Nature; 488; 7411; 8-2012; 370-374 0028-0836 CONICET Digital CONICET |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
op_doi |
https://doi.org/10.1038/nature11258 |
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Nature |
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488 |
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7411 |
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374 |
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