Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations

• Main Authors: Lucia F. Jorge-nebert, Zhengwen Jiang, Ranajit Chakraborty, Joanna Watson, Li Jin, Stephen T. Mcgarvey, Ranjan Deka, Daniel W. Nebert
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: Pehuenche; Dogrib
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.666.6919; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837/pdf/nihms-148388.pdf

The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene m...