Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations
The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene m...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.666.6919 2023-05-15T16:02:14+02:00 Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations Lucia F. Jorge-nebert Zhengwen Jiang Ranajit Chakraborty Joanna Watson Li Jin Stephen T. Mcgarvey Ranjan Deka Daniel W. Nebert The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.666.6919 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837/pdf/nihms-148388.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.666.6919 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837/pdf/nihms-148388.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837/pdf/nihms-148388.pdf text ftciteseerx 2016-01-08T17:07:56Z The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene might have evolved more rapidly due to environmental (dietary) pressures. A population genetics study might confirm this premise. We combined 60 CYP1A1_CYP1A2 SNPs found in the present study (eight New Guinea Highlanders, eight Samoans, four Dogrib, four Teribe, four Pehuenche, one Caucasian) with those found in a previous study (six West Africans, four Han Chinese, six Germans, four Samoans, and four Dogrib)—yielding a total of 106 SNPs in 106 chromosomes. Resequencing of Oceanians plus Amerindians in the present study yielded 21 New World SNPs (~20%), of which 17 are not previously reported in any SNP database. Various tests revealed selective pressures for both genes and both haploblocks; unfortunately, differences in rates of evolution between the two genes were undetectable. Fay & Wu's H test revealed a “hitchhiking event ” centered around four SNPs in the CYP1A1 3'-UTR; a study in silico identified different microRNA-binding patterns in the hitchhiked region, when the mutations were present compared with the mutations absent. Text Dogrib Unknown Pehuenche ENVELOPE(-60.783,-60.783,-62.450,-62.450) |
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English |
description |
The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene might have evolved more rapidly due to environmental (dietary) pressures. A population genetics study might confirm this premise. We combined 60 CYP1A1_CYP1A2 SNPs found in the present study (eight New Guinea Highlanders, eight Samoans, four Dogrib, four Teribe, four Pehuenche, one Caucasian) with those found in a previous study (six West Africans, four Han Chinese, six Germans, four Samoans, and four Dogrib)—yielding a total of 106 SNPs in 106 chromosomes. Resequencing of Oceanians plus Amerindians in the present study yielded 21 New World SNPs (~20%), of which 17 are not previously reported in any SNP database. Various tests revealed selective pressures for both genes and both haploblocks; unfortunately, differences in rates of evolution between the two genes were undetectable. Fay & Wu's H test revealed a “hitchhiking event ” centered around four SNPs in the CYP1A1 3'-UTR; a study in silico identified different microRNA-binding patterns in the hitchhiked region, when the mutations were present compared with the mutations absent. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Lucia F. Jorge-nebert Zhengwen Jiang Ranajit Chakraborty Joanna Watson Li Jin Stephen T. Mcgarvey Ranjan Deka Daniel W. Nebert |
spellingShingle |
Lucia F. Jorge-nebert Zhengwen Jiang Ranajit Chakraborty Joanna Watson Li Jin Stephen T. Mcgarvey Ranjan Deka Daniel W. Nebert Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
author_facet |
Lucia F. Jorge-nebert Zhengwen Jiang Ranajit Chakraborty Joanna Watson Li Jin Stephen T. Mcgarvey Ranjan Deka Daniel W. Nebert |
author_sort |
Lucia F. Jorge-nebert |
title |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_short |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_full |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_fullStr |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_full_unstemmed |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_sort |
analysis of human cyp1a1 and cyp1a2 genes and their shared bidirectional promoter in eight world populations |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.666.6919 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837/pdf/nihms-148388.pdf |
long_lat |
ENVELOPE(-60.783,-60.783,-62.450,-62.450) |
geographic |
Pehuenche |
geographic_facet |
Pehuenche |
genre |
Dogrib |
genre_facet |
Dogrib |
op_source |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837/pdf/nihms-148388.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.666.6919 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837/pdf/nihms-148388.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766397816360402944 |