GY Minuk, S Liu, K Kaita, et al. Autoimmune hepatitis in a North American Aboriginal/First Nations population. Can J
North American Aboriginal populations are at increased risk for developing immune-mediated disorders, including autoimmune hep-atitis. In the present study, the demographic, clinical, biochemical, serological, radiological and histological features of autoimmune hep-atitis were compared in 33 First...
Main Authors: | , , , , , , , |
---|---|
Other Authors: | |
Format: | Text |
Language: | English |
Published: |
2008
|
Subjects: | |
Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.1778 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661303/pdf/cjg22829.pdf?origin%3Dpublication_detail |
id |
ftciteseerx:oai:CiteSeerX.psu:10.1.1.656.1778 |
---|---|
record_format |
openpolar |
spelling |
ftciteseerx:oai:CiteSeerX.psu:10.1.1.656.1778 2023-05-15T16:15:20+02:00 GY Minuk, S Liu, K Kaita, et al. Autoimmune hepatitis in a North American Aboriginal/First Nations population. Can J Gy Minuk Md S Liu Bsc K Kaita Md S Wong Md E Renner Md J Rempel Phd J Uhanova Md Msc The Pennsylvania State University CiteSeerX Archives 2008 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.1778 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661303/pdf/cjg22829.pdf?origin%3Dpublication_detail en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.1778 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661303/pdf/cjg22829.pdf?origin%3Dpublication_detail Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661303/pdf/cjg22829.pdf?origin%3Dpublication_detail Key Words Aboriginal Autoimmune hepatitis Cirrhosis First Nations Hepatitis Liver disease L’hépatite auto-immune au sein d’une text 2008 ftciteseerx 2016-01-08T16:37:07Z North American Aboriginal populations are at increased risk for developing immune-mediated disorders, including autoimmune hep-atitis. In the present study, the demographic, clinical, biochemical, serological, radiological and histological features of autoimmune hep-atitis were compared in 33 First Nations (FN) and 150 predominantly Caucasian, non-FN patients referred to an urban tertiary care centre. FN patients were more often female (91 % versus 71%; P=0.04), and more likely to have low serum albumin (69 % versus 36%; P=0.0006) and elevated bilirubin (57 % versus 35%; P=0.01) levels on presenta-tion compared with non-FN patients. They also had lower hemoglo-bin, and complement levels, more cholestasis and higher serum immunoglobulin A levels than non-FN patients (P=0.05 respec-tively). Higher histological grades of inflammation and stages of fibrosis, and more clinical and radiological evidence of advanced liver disease were observed in FN patients, but the differences failed to reach statistical significance. The results of the present study suggest that in addition to being more common, autoimmune hepatitis may be more severe in FN populations, compared with predominantly Caucasian, non-FN populations. Text First Nations Unknown |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
ftciteseerx |
language |
English |
topic |
Key Words Aboriginal Autoimmune hepatitis Cirrhosis First Nations Hepatitis Liver disease L’hépatite auto-immune au sein d’une |
spellingShingle |
Key Words Aboriginal Autoimmune hepatitis Cirrhosis First Nations Hepatitis Liver disease L’hépatite auto-immune au sein d’une Gy Minuk Md S Liu Bsc K Kaita Md S Wong Md E Renner Md J Rempel Phd J Uhanova Md Msc GY Minuk, S Liu, K Kaita, et al. Autoimmune hepatitis in a North American Aboriginal/First Nations population. Can J |
topic_facet |
Key Words Aboriginal Autoimmune hepatitis Cirrhosis First Nations Hepatitis Liver disease L’hépatite auto-immune au sein d’une |
description |
North American Aboriginal populations are at increased risk for developing immune-mediated disorders, including autoimmune hep-atitis. In the present study, the demographic, clinical, biochemical, serological, radiological and histological features of autoimmune hep-atitis were compared in 33 First Nations (FN) and 150 predominantly Caucasian, non-FN patients referred to an urban tertiary care centre. FN patients were more often female (91 % versus 71%; P=0.04), and more likely to have low serum albumin (69 % versus 36%; P=0.0006) and elevated bilirubin (57 % versus 35%; P=0.01) levels on presenta-tion compared with non-FN patients. They also had lower hemoglo-bin, and complement levels, more cholestasis and higher serum immunoglobulin A levels than non-FN patients (P=0.05 respec-tively). Higher histological grades of inflammation and stages of fibrosis, and more clinical and radiological evidence of advanced liver disease were observed in FN patients, but the differences failed to reach statistical significance. The results of the present study suggest that in addition to being more common, autoimmune hepatitis may be more severe in FN populations, compared with predominantly Caucasian, non-FN populations. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Gy Minuk Md S Liu Bsc K Kaita Md S Wong Md E Renner Md J Rempel Phd J Uhanova Md Msc |
author_facet |
Gy Minuk Md S Liu Bsc K Kaita Md S Wong Md E Renner Md J Rempel Phd J Uhanova Md Msc |
author_sort |
Gy Minuk Md |
title |
GY Minuk, S Liu, K Kaita, et al. Autoimmune hepatitis in a North American Aboriginal/First Nations population. Can J |
title_short |
GY Minuk, S Liu, K Kaita, et al. Autoimmune hepatitis in a North American Aboriginal/First Nations population. Can J |
title_full |
GY Minuk, S Liu, K Kaita, et al. Autoimmune hepatitis in a North American Aboriginal/First Nations population. Can J |
title_fullStr |
GY Minuk, S Liu, K Kaita, et al. Autoimmune hepatitis in a North American Aboriginal/First Nations population. Can J |
title_full_unstemmed |
GY Minuk, S Liu, K Kaita, et al. Autoimmune hepatitis in a North American Aboriginal/First Nations population. Can J |
title_sort |
gy minuk, s liu, k kaita, et al. autoimmune hepatitis in a north american aboriginal/first nations population. can j |
publishDate |
2008 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.1778 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661303/pdf/cjg22829.pdf?origin%3Dpublication_detail |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661303/pdf/cjg22829.pdf?origin%3Dpublication_detail |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.1778 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661303/pdf/cjg22829.pdf?origin%3Dpublication_detail |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766001075652919296 |