RESEARCH Omega-3 fatty acids, poly e R

• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: Nutrigenetics; n-3 PUFAs; Plasma lipids; Gene-nutrient interactions; inuit
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.644.1026; http://www.nutritionandmetabolism.com/content/pdf/1743-7075-10-26.pdf

Full list of author information is available at the end of the articleBackground The lifestyle of the Inuit is rapidly changing towards an increased cardiovascular (CVD) risk factor profile [1]. The CVD risk factors include non-modifiable risk fac-tors such as age, male sex, family history, and modifiable risk factors for example smoking, hypertension, diabetes, and hyperlipidemia. Specifically, improving plasma lipids profile – including: total cholesterol (TC), triacylglycerol (TG), low-density-lipoprotein cholesterol (LDL-C), apo-lipoprotein (apo) B concentrations, apo A1 concentra-tions and high-density-lipoprotein cholesterol (HDL-C)-is associated with a decreased CVD risk [2]. Studies have shown that both environmental and genetic factors may play a role in determining susceptibility to dyslipidemia. The consumption of fish and marine mammals rich in n-3 PUFAs represents an important dietary component for CVD risk prevention in the Inuit population [3]. A high intake of n-3 polyunsaturated fatty acids (n-3