Expression of a duplicate Na,K-ATPase b1 isoform in the European eel (Anguilla anguilla

• Main Authors: Christopher P. Cutler, Stephane Brezillon, Songul Bekir, Ian L. Sanders, Neil Hazon, Gordon Cramb, Christopher P, Ian L. S
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Published: 2000
• Subjects: Anguilla anguilla
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.597.8407; http://www.bio.georgiasouthern.edu/Bio-home/Cutler/EelNa,K-ATPaseb233.pdf

Integrative Comp Physiol 279: R222–R229, 2000.—Recent studies on teleost fish have suggested that their genomes have undergone ancient polyploidization events resulting in the duplication of the genome. A duplicate copy of the Na,K-ATPase b1-isoform (called b233) has been identified in the European eel (Anguilla anguilla). The b233-isoform shares high levels of nucleotide (74.8%) and amino acid (69.9%) homology with the eel b1-subunit as well as other vertebrate b1-sequences. Compared with the widely expressed b1-iso-form, expression of b233-mRNA is mainly restricted to epi-thelial tissues. Seawater acclimation induced increases in b233-mRNA levels in kidney, gill, and intestine of migratory “silver ” but not the nonmigratory “yellow ” adult eels, sug-gesting that the factors responsible for this upregulation are themselves developmentally regulated. Expression of a vari-