Evaluation of Fish Early LifeStage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures
Polycyclic aromatic hydrocarbons (PAHs) can cause a variety of effects in early life-stages of fish that have been chronically ex-posed as embryos, including mortality, deformities, and edemas. Mechanistic models of the chronic toxicity of complex mixtures of PAHs in fish have not been reported, wit...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.587.1054 2023-05-15T17:59:39+02:00 Evaluation of Fish Early LifeStage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures Mace G. Barron Mark G. Carls Ron Heintz Stanley D. Rice The Pennsylvania State University CiteSeerX Archives 2004 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.587.1054 http://toxsci.oxfordjournals.org/content/78/1/60.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.587.1054 http://toxsci.oxfordjournals.org/content/78/1/60.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://toxsci.oxfordjournals.org/content/78/1/60.full.pdf text 2004 ftciteseerx 2016-01-08T13:18:22Z Polycyclic aromatic hydrocarbons (PAHs) can cause a variety of effects in early life-stages of fish that have been chronically ex-posed as embryos, including mortality, deformities, and edemas. Mechanistic models of the chronic toxicity of complex mixtures of PAHs in fish have not been reported, with the exception of a previously untested model based on the lipids of fish as the site of action and toxicity caused through a narcosis mechanism. Four mechanism-based models of the chronic toxicity of embryonic exposures to complex mixtures of petrogenic PAHs in two species of fish, Pacific herring and pink salmon, were evaluated using a toxic-units approach: narcosis, aryl hydrocarbon receptor (AhR) agonism, alkyl phenanthrene toxicity, and combined toxicity. Al-kyl phenanthrenes were the predominant PAH constituent deter-mining early life-stage toxicity in both herring and salmon. The alkyl phenanthrene model had 67 to 80 % accuracy in predicting Text Pink salmon Unknown Pacific |
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Open Polar |
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Unknown |
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ftciteseerx |
language |
English |
description |
Polycyclic aromatic hydrocarbons (PAHs) can cause a variety of effects in early life-stages of fish that have been chronically ex-posed as embryos, including mortality, deformities, and edemas. Mechanistic models of the chronic toxicity of complex mixtures of PAHs in fish have not been reported, with the exception of a previously untested model based on the lipids of fish as the site of action and toxicity caused through a narcosis mechanism. Four mechanism-based models of the chronic toxicity of embryonic exposures to complex mixtures of petrogenic PAHs in two species of fish, Pacific herring and pink salmon, were evaluated using a toxic-units approach: narcosis, aryl hydrocarbon receptor (AhR) agonism, alkyl phenanthrene toxicity, and combined toxicity. Al-kyl phenanthrenes were the predominant PAH constituent deter-mining early life-stage toxicity in both herring and salmon. The alkyl phenanthrene model had 67 to 80 % accuracy in predicting |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Mace G. Barron Mark G. Carls Ron Heintz Stanley D. Rice |
spellingShingle |
Mace G. Barron Mark G. Carls Ron Heintz Stanley D. Rice Evaluation of Fish Early LifeStage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures |
author_facet |
Mace G. Barron Mark G. Carls Ron Heintz Stanley D. Rice |
author_sort |
Mace G. Barron |
title |
Evaluation of Fish Early LifeStage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures |
title_short |
Evaluation of Fish Early LifeStage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures |
title_full |
Evaluation of Fish Early LifeStage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures |
title_fullStr |
Evaluation of Fish Early LifeStage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures |
title_full_unstemmed |
Evaluation of Fish Early LifeStage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures |
title_sort |
evaluation of fish early lifestage toxicity models of chronic embryonic exposures to complex polycyclic aromatic hydrocarbon mixtures |
publishDate |
2004 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.587.1054 http://toxsci.oxfordjournals.org/content/78/1/60.full.pdf |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Pink salmon |
genre_facet |
Pink salmon |
op_source |
http://toxsci.oxfordjournals.org/content/78/1/60.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.587.1054 http://toxsci.oxfordjournals.org/content/78/1/60.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766168496638525440 |