doi:10.1046/j.1529-8817.2003.00127.x Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups
In search of the ancestors of Native American mitochondrial DNA (mtDNA) haplogroups, we analyzed the mtDNA of 531 individuals from nine indigenous populations in Siberia. All mtDNAs were subjected to high-resolution RFLP analysis, sequencing of the control-region hypervariable segment I (HVS-I), and...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.585.6060 2023-05-15T15:00:42+02:00 doi:10.1046/j.1529-8817.2003.00127.x Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups Elena B. Starikovskaya Natalia V. Volodko Eduardo Ruiz-pesini Antonio Torroni Michael D. Brown Marie T. Lott Seyed H. Hosseini Kirsi Huoponen Douglas C. Wallace The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.6060 http://www.bionet.nsc.ru/labs/mtgenome/Publications/Starikovskaya2005.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.6060 http://www.bionet.nsc.ru/labs/mtgenome/Publications/Starikovskaya2005.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://www.bionet.nsc.ru/labs/mtgenome/Publications/Starikovskaya2005.pdf text ftciteseerx 2016-01-08T13:14:49Z In search of the ancestors of Native American mitochondrial DNA (mtDNA) haplogroups, we analyzed the mtDNA of 531 individuals from nine indigenous populations in Siberia. All mtDNAs were subjected to high-resolution RFLP analysis, sequencing of the control-region hypervariable segment I (HVS-I), and surveyed for additional polymorphic markers in the coding region. Furthermore, the mtDNAs selected according to haplogroup/subhaplogroup status were completely sequenced. Phylogenetic analyses of the resulting data, combined with those from previously published Siberian arctic and sub-arctic populations, revealed that remnants of the ancient Siberian gene pool are still evident in Siberian populations, suggesting that the founding haplotypes of the Native American A-D branches originated in different parts of Siberia. Thus, lineage A complete sequences revealed in the Mansi of the Lower Ob and the Ket of the Lower Yenisei belong to A1, suggesting that A1 mtDNAs occasionally found in the remnants of hunting-gathering populations of northwestern and northern Siberia belonged to a common gene pool of the Siberian progenitors of Paleoindians. Moreover, lineage B1, which is the most closely related to the American B2, occurred in the Tubalar and Tuvan inhabiting the territory between the upper reaches of the Ob River in the west, to the Upper Yenisei region in the east. Finally, the sequence variants of haplogroups C and D, which are most similar to Native American C1 and D1, were detected in the Ulchi of the Lower Amur. Overall, our data suggest that the immediate ancestors of the Siberian/Beringian migrants who gave rise to ancient (pre-Clovis) Paleoindians Text Arctic ob river Mansi Siberia Unknown Arctic |
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In search of the ancestors of Native American mitochondrial DNA (mtDNA) haplogroups, we analyzed the mtDNA of 531 individuals from nine indigenous populations in Siberia. All mtDNAs were subjected to high-resolution RFLP analysis, sequencing of the control-region hypervariable segment I (HVS-I), and surveyed for additional polymorphic markers in the coding region. Furthermore, the mtDNAs selected according to haplogroup/subhaplogroup status were completely sequenced. Phylogenetic analyses of the resulting data, combined with those from previously published Siberian arctic and sub-arctic populations, revealed that remnants of the ancient Siberian gene pool are still evident in Siberian populations, suggesting that the founding haplotypes of the Native American A-D branches originated in different parts of Siberia. Thus, lineage A complete sequences revealed in the Mansi of the Lower Ob and the Ket of the Lower Yenisei belong to A1, suggesting that A1 mtDNAs occasionally found in the remnants of hunting-gathering populations of northwestern and northern Siberia belonged to a common gene pool of the Siberian progenitors of Paleoindians. Moreover, lineage B1, which is the most closely related to the American B2, occurred in the Tubalar and Tuvan inhabiting the territory between the upper reaches of the Ob River in the west, to the Upper Yenisei region in the east. Finally, the sequence variants of haplogroups C and D, which are most similar to Native American C1 and D1, were detected in the Ulchi of the Lower Amur. Overall, our data suggest that the immediate ancestors of the Siberian/Beringian migrants who gave rise to ancient (pre-Clovis) Paleoindians |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Elena B. Starikovskaya Natalia V. Volodko Eduardo Ruiz-pesini Antonio Torroni Michael D. Brown Marie T. Lott Seyed H. Hosseini Kirsi Huoponen Douglas C. Wallace |
spellingShingle |
Elena B. Starikovskaya Natalia V. Volodko Eduardo Ruiz-pesini Antonio Torroni Michael D. Brown Marie T. Lott Seyed H. Hosseini Kirsi Huoponen Douglas C. Wallace doi:10.1046/j.1529-8817.2003.00127.x Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups |
author_facet |
Elena B. Starikovskaya Natalia V. Volodko Eduardo Ruiz-pesini Antonio Torroni Michael D. Brown Marie T. Lott Seyed H. Hosseini Kirsi Huoponen Douglas C. Wallace |
author_sort |
Elena B. Starikovskaya |
title |
doi:10.1046/j.1529-8817.2003.00127.x Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups |
title_short |
doi:10.1046/j.1529-8817.2003.00127.x Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups |
title_full |
doi:10.1046/j.1529-8817.2003.00127.x Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups |
title_fullStr |
doi:10.1046/j.1529-8817.2003.00127.x Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups |
title_full_unstemmed |
doi:10.1046/j.1529-8817.2003.00127.x Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups |
title_sort |
doi:10.1046/j.1529-8817.2003.00127.x mitochondrial dna diversity in indigenous populations of the southern extent of siberia, and the origins of native american haplogroups |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.6060 http://www.bionet.nsc.ru/labs/mtgenome/Publications/Starikovskaya2005.pdf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic ob river Mansi Siberia |
genre_facet |
Arctic ob river Mansi Siberia |
op_source |
http://www.bionet.nsc.ru/labs/mtgenome/Publications/Starikovskaya2005.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.6060 http://www.bionet.nsc.ru/labs/mtgenome/Publications/Starikovskaya2005.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766332777521741824 |