Species-Dependent Variations in the in Vitro Myotoxicity of Death Adder (Acanthophis) Venoms
Based on early studies on Acanthophis antarcticus (common death adder) venom, it has long been thought that death adder snake venoms are devoid of myotoxicity. However, a recent clin-ical study reported rhabdomyolysis in patients following death adder envenomations, in Papua New Guinea, by a species...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.580.7883 2023-05-15T13:32:27+02:00 Species-Dependent Variations in the in Vitro Myotoxicity of Death Adder (Acanthophis) Venoms Janith C. Wickramaratna Bryan G. Fry Wayne C. Hodgson The Pennsylvania State University CiteSeerX Archives 2003 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.7883 http://toxsci.oxfordjournals.org/content/74/2/352.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.7883 http://toxsci.oxfordjournals.org/content/74/2/352.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://toxsci.oxfordjournals.org/content/74/2/352.full.pdf sis A. rugosus venom text 2003 ftciteseerx 2016-01-08T13:00:59Z Based on early studies on Acanthophis antarcticus (common death adder) venom, it has long been thought that death adder snake venoms are devoid of myotoxicity. However, a recent clin-ical study reported rhabdomyolysis in patients following death adder envenomations, in Papua New Guinea, by a species thought to be different to A. antarcticus. Subsequently, a myotoxic phos-pholipase A2 component was isolated from A. rugosus (Irian Jayan death adder) venom. The present study examined the venoms of A. praelongus (northern), A. pyrrhus (desert), A. hawkei (Barkly Tableland), A. wellsi (black head), A. rugosus, A. sp. Seram and the regional variants of A. antarcticus for in vitro myotoxicity. Venoms (10–50 g/ml) were examined for myotoxicity using the chick directly (0.1 Hz, 2 ms, supramaximal V) stimulated biventer cervicis nerve-muscle preparation. A significant contracture of skeletal muscle and/or inhibition of direct twitches were consid- Text Antarc* antarcticus Unknown |
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sis A. rugosus venom |
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sis A. rugosus venom Janith C. Wickramaratna Bryan G. Fry Wayne C. Hodgson Species-Dependent Variations in the in Vitro Myotoxicity of Death Adder (Acanthophis) Venoms |
topic_facet |
sis A. rugosus venom |
description |
Based on early studies on Acanthophis antarcticus (common death adder) venom, it has long been thought that death adder snake venoms are devoid of myotoxicity. However, a recent clin-ical study reported rhabdomyolysis in patients following death adder envenomations, in Papua New Guinea, by a species thought to be different to A. antarcticus. Subsequently, a myotoxic phos-pholipase A2 component was isolated from A. rugosus (Irian Jayan death adder) venom. The present study examined the venoms of A. praelongus (northern), A. pyrrhus (desert), A. hawkei (Barkly Tableland), A. wellsi (black head), A. rugosus, A. sp. Seram and the regional variants of A. antarcticus for in vitro myotoxicity. Venoms (10–50 g/ml) were examined for myotoxicity using the chick directly (0.1 Hz, 2 ms, supramaximal V) stimulated biventer cervicis nerve-muscle preparation. A significant contracture of skeletal muscle and/or inhibition of direct twitches were consid- |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Janith C. Wickramaratna Bryan G. Fry Wayne C. Hodgson |
author_facet |
Janith C. Wickramaratna Bryan G. Fry Wayne C. Hodgson |
author_sort |
Janith C. Wickramaratna |
title |
Species-Dependent Variations in the in Vitro Myotoxicity of Death Adder (Acanthophis) Venoms |
title_short |
Species-Dependent Variations in the in Vitro Myotoxicity of Death Adder (Acanthophis) Venoms |
title_full |
Species-Dependent Variations in the in Vitro Myotoxicity of Death Adder (Acanthophis) Venoms |
title_fullStr |
Species-Dependent Variations in the in Vitro Myotoxicity of Death Adder (Acanthophis) Venoms |
title_full_unstemmed |
Species-Dependent Variations in the in Vitro Myotoxicity of Death Adder (Acanthophis) Venoms |
title_sort |
species-dependent variations in the in vitro myotoxicity of death adder (acanthophis) venoms |
publishDate |
2003 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.7883 http://toxsci.oxfordjournals.org/content/74/2/352.full.pdf |
genre |
Antarc* antarcticus |
genre_facet |
Antarc* antarcticus |
op_source |
http://toxsci.oxfordjournals.org/content/74/2/352.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.7883 http://toxsci.oxfordjournals.org/content/74/2/352.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766027161347555328 |