The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS
The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homoge...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.575.9483 2023-05-15T16:46:17+02:00 The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS Alkes L. Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St. Clair Ole A David Reich Augustine Kong Kari Stefansson The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.575.9483 http://genepath.med.harvard.edu/~reich/2009_PLoS_Genetics_Price_Iceland_Structure.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.575.9483 http://genepath.med.harvard.edu/~reich/2009_PLoS_Genetics_Price_Iceland_Structure.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://genepath.med.harvard.edu/~reich/2009_PLoS_Genetics_Price_Iceland_Structure.pdf text ftciteseerx 2016-01-08T12:45:25Z The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homogeneous, but exhibits subtle population structure that can bias disease association statistics. Here, we show that regional geographic ancestries of individuals from Iceland can be distinguished using 292,289 autosomal single-nucleotide polymorphisms (SNPs). We further show that subpopulation differences are due to genetic drift since the settlement of Iceland 1100 years ago, and not to varying contributions from different ancestral populations. A consequence of the recent origin of Icelandic population structure is that allele frequency differences follow a null distribution devoid of outliers, so that the risk of false positive associations due to stratification is minimal. Our results highlight an important distinction between population differences attributable to recent drift and those arising from more ancient divergence, which has implications both for association studies and for Text Iceland Unknown |
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The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homogeneous, but exhibits subtle population structure that can bias disease association statistics. Here, we show that regional geographic ancestries of individuals from Iceland can be distinguished using 292,289 autosomal single-nucleotide polymorphisms (SNPs). We further show that subpopulation differences are due to genetic drift since the settlement of Iceland 1100 years ago, and not to varying contributions from different ancestral populations. A consequence of the recent origin of Icelandic population structure is that allele frequency differences follow a null distribution devoid of outliers, so that the risk of false positive associations due to stratification is minimal. Our results highlight an important distinction between population differences attributable to recent drift and those arising from more ancient divergence, which has implications both for association studies and for |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Alkes L. Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St. Clair Ole A David Reich Augustine Kong Kari Stefansson |
spellingShingle |
Alkes L. Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St. Clair Ole A David Reich Augustine Kong Kari Stefansson The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS |
author_facet |
Alkes L. Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St. Clair Ole A David Reich Augustine Kong Kari Stefansson |
author_sort |
Alkes L. Price |
title |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS |
title_short |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS |
title_full |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS |
title_fullStr |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS |
title_full_unstemmed |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland.” PLoS |
title_sort |
impact of divergence time on the nature of population structure: an example from iceland.” plos |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.575.9483 http://genepath.med.harvard.edu/~reich/2009_PLoS_Genetics_Price_Iceland_Structure.pdf |
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Iceland |
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Iceland |
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http://genepath.med.harvard.edu/~reich/2009_PLoS_Genetics_Price_Iceland_Structure.pdf |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.575.9483 http://genepath.med.harvard.edu/~reich/2009_PLoS_Genetics_Price_Iceland_Structure.pdf |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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