Bystander effects induced by “Multiple Stressor ” exposure to sublethal radiation and heavy metals in Atlantic Salmon

These experiments were designed to identify cellular effects in 3 key organs in Atlantic Salmon (Salmo salar, L.) after exposure in vivo to very low doses of radiation, and subtoxic levels of aluminum (Al) and cadmium (Cd) alone or in combination. The data suggest that using bystander signal toxicit...

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Bibliographic Details
Main Authors: Seymour C. B, Mothersill C, Denbeigh J, Heier L. S, Teien H. C, Oughton D. H, Salbu B
Other Authors: The Pennsylvania State University CiteSeerX Archives
Format: Text
Language:English
Subjects:
Atlantic salmon
Salmo salar
Online Access:http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.573.952
http://www.radioecology.info/Bergen2008/proceedings/162. Mothersill C. O.pdf
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Summary:These experiments were designed to identify cellular effects in 3 key organs in Atlantic Salmon (Salmo salar, L.) after exposure in vivo to very low doses of radiation, and subtoxic levels of aluminum (Al) and cadmium (Cd) alone or in combination. The data suggest that using bystander signal toxicity as an endpoint in a reporter cell line, sub-additive effects are most commonly seen following mixed exposures. It is not clear if these result from saturation effects or represent toxic effects of one agent preventing the other from inducing apoptotic pathways.

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