Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland
Aims To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defin...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.563.6509 2023-05-15T16:51:17+02:00 Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland David O. Arnar Sverrir Thorvaldsson Teri A. Manolio Gudmundur Thorgeirsson Kristleifur Kristjansson Hakon Hakonarson Kari Stefansson The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.563.6509 http://eurheartj.oxfordjournals.org/content/27/6/708.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.563.6509 http://eurheartj.oxfordjournals.org/content/27/6/708.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://eurheartj.oxfordjournals.org/content/27/6/708.full.pdf text ftciteseerx 2016-01-08T12:09:34Z Aims To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined. Methods and results The study population included 5269 patients diagnosed since 1987 and age-sex-matched controls randomly selected from the genealogy database. Kinship coefficients (KC), expressed as genealogical index of familiality (GIF average KC 100 000), were calculated before and after exclusion of relatives separated by one to five meiotic events. Risk ratios (RR) were calculated for first- to fifth-degree relatives. The average pairwise GIF among patients with AF was 15.9 (mean GIF for controls 13.9, 95%CI 13.3, 14.4); this declined to 15.4 (mean GIF for controls 13.6, 95%CI 13.1, 14.2) after exclusion of relatives separated by one meiosis and to 13.7 (mean GIF for con-trols 12.6, 95%CI 12.1, 13.2), 12.7 (mean GIF for controls 11.9, 95%CI 11.4, 12.4), and 11.3 (mean GIF for controls 10.6, 95%CI 10.1, 11.1) after exclusion of relatives within two, three, and four meioses, respectively (all P, 0.00001). RRs among relative pairs also declined incrementally, from 1.77 in first-degree relatives to 1.36, 1.18, 1.10, and 1.05 in second- through fifth-degree relatives (all P, 0.001), consistent with the declining proportion of alleles shared identically by descent. Text Iceland Unknown |
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description |
Aims To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined. Methods and results The study population included 5269 patients diagnosed since 1987 and age-sex-matched controls randomly selected from the genealogy database. Kinship coefficients (KC), expressed as genealogical index of familiality (GIF average KC 100 000), were calculated before and after exclusion of relatives separated by one to five meiotic events. Risk ratios (RR) were calculated for first- to fifth-degree relatives. The average pairwise GIF among patients with AF was 15.9 (mean GIF for controls 13.9, 95%CI 13.3, 14.4); this declined to 15.4 (mean GIF for controls 13.6, 95%CI 13.1, 14.2) after exclusion of relatives separated by one meiosis and to 13.7 (mean GIF for con-trols 12.6, 95%CI 12.1, 13.2), 12.7 (mean GIF for controls 11.9, 95%CI 11.4, 12.4), and 11.3 (mean GIF for controls 10.6, 95%CI 10.1, 11.1) after exclusion of relatives within two, three, and four meioses, respectively (all P, 0.00001). RRs among relative pairs also declined incrementally, from 1.77 in first-degree relatives to 1.36, 1.18, 1.10, and 1.05 in second- through fifth-degree relatives (all P, 0.001), consistent with the declining proportion of alleles shared identically by descent. |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
David O. Arnar Sverrir Thorvaldsson Teri A. Manolio Gudmundur Thorgeirsson Kristleifur Kristjansson Hakon Hakonarson Kari Stefansson |
spellingShingle |
David O. Arnar Sverrir Thorvaldsson Teri A. Manolio Gudmundur Thorgeirsson Kristleifur Kristjansson Hakon Hakonarson Kari Stefansson Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland |
author_facet |
David O. Arnar Sverrir Thorvaldsson Teri A. Manolio Gudmundur Thorgeirsson Kristleifur Kristjansson Hakon Hakonarson Kari Stefansson |
author_sort |
David O. Arnar |
title |
Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland |
title_short |
Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland |
title_full |
Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland |
title_fullStr |
Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland |
title_full_unstemmed |
Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland |
title_sort |
clinical research arrhythmia/electrophysiology familial aggregation of atrial fibrillation in iceland |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.563.6509 http://eurheartj.oxfordjournals.org/content/27/6/708.full.pdf |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
http://eurheartj.oxfordjournals.org/content/27/6/708.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.563.6509 http://eurheartj.oxfordjournals.org/content/27/6/708.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766041395377733632 |