c © Indian Academy of Sciences RESEARCH ARTICLE Evolutionary history of the somatostatin and somatostatin receptors

• Main Authors: Muhammad Moaeen-ud-din, Li Guo Yang
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: Indian; Canis lupus
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.559.6208; http://www.ias.ac.in/jgenet/Vol88No1/41.pdf

Somatostatin and its receptors have a critical role in mammalian growth through their control pattern of secretion of growth hormone, but the evolutionary history of somatostatin and somatostatin receptors are ill defined. We used comparative whole genome analysis of Danio rerio, Carassius auratus, Xenopus tropicalis, Gallus gallus, Monodelphis domestica, Homo sapi-ens, Sus scrofa, Bos taurus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Ovis aries, Equus caballus, Pan troglodytes and Macaca mulatto to identify somatostatin and somatostatin receptors in each species. To date, we have identi-fied a minimum of two genes of somatostatin and five somatostatin receptor genes in mammalian species with variable forms. We established a clear evolutionary history of the somatostatin system and traced the origin of the somatostatin system to 395 million years ago (MYA), identifying critical steps in their evolution. [Moaeen-ud-Din M. and Yang L. G. 2009 Evolutionary history of the somatostatin and somatostatin receptors. J. Genet. 88, 41–53]