2 Arctic Region Supercomputing Center
Alternative initiation, splicing, and polyadenylation are key mechanisms used by many organisms to generate diversity among mature mRNA transcripts originating from the same transcription unit. While previous computational analyses of alternative polyadenylation have focused on polyadenylation activ...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.556.3229 2023-05-15T15:02:39+02:00 2 Arctic Region Supercomputing Center Jun Yan Thomas G. Marr The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.556.3229 http://physics.nyu.edu/~jy272/altA/altA.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.556.3229 http://physics.nyu.edu/~jy272/altA/altA.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://physics.nyu.edu/~jy272/altA/altA.pdf text ftciteseerx 2016-01-08T11:47:32Z Alternative initiation, splicing, and polyadenylation are key mechanisms used by many organisms to generate diversity among mature mRNA transcripts originating from the same transcription unit. While previous computational analyses of alternative polyadenylation have focused on polyadenylation activities within or downstream of the normal 3 ' terminal exons, we present the results of the first genome-wide analysis of patterns of alternative polyadenylation in the human, mouse, and rat genomes occurring over the entire transcribed regions of mRNAs using 3 ' ESTs with polyA tails aligned to genomic sequences. Four distinct classes of patterns of alternative polyadenylation result from this analysis: tandem polyA sites, composite exons, hidden exons, and truncated exons. We estimate that at least 49% (human), 31 % (mouse), and 28 % (rat) of polyadenylated transcription units have alternative polyadenylation. A portion of these alternative polyadenylation events result in new protein isoforms. Text Arctic Unknown Arctic |
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Alternative initiation, splicing, and polyadenylation are key mechanisms used by many organisms to generate diversity among mature mRNA transcripts originating from the same transcription unit. While previous computational analyses of alternative polyadenylation have focused on polyadenylation activities within or downstream of the normal 3 ' terminal exons, we present the results of the first genome-wide analysis of patterns of alternative polyadenylation in the human, mouse, and rat genomes occurring over the entire transcribed regions of mRNAs using 3 ' ESTs with polyA tails aligned to genomic sequences. Four distinct classes of patterns of alternative polyadenylation result from this analysis: tandem polyA sites, composite exons, hidden exons, and truncated exons. We estimate that at least 49% (human), 31 % (mouse), and 28 % (rat) of polyadenylated transcription units have alternative polyadenylation. A portion of these alternative polyadenylation events result in new protein isoforms. |
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The Pennsylvania State University CiteSeerX Archives |
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Text |
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Jun Yan Thomas G. Marr |
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Jun Yan Thomas G. Marr 2 Arctic Region Supercomputing Center |
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Jun Yan Thomas G. Marr |
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Jun Yan |
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2 Arctic Region Supercomputing Center |
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2 Arctic Region Supercomputing Center |
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2 Arctic Region Supercomputing Center |
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2 Arctic Region Supercomputing Center |
title_full_unstemmed |
2 Arctic Region Supercomputing Center |
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2 arctic region supercomputing center |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.556.3229 http://physics.nyu.edu/~jy272/altA/altA.pdf |
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Arctic |
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Arctic |
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Arctic |
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http://physics.nyu.edu/~jy272/altA/altA.pdf |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.556.3229 http://physics.nyu.edu/~jy272/altA/altA.pdf |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766334575578972160 |