CORRESPONDENCE Re: MLH1 − 93G>A Promoter
Raptis et al. ( 1) propose an association be-tween the MLH1 − 93G>A polymorphism and colorectal cancers with high micro-satellite instability (MSI-H) status and sug-gest that this variant is a low-penetrance allele for colorectal cancer susceptibility. Although it is plausible that, in addition t...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.555.9537 2023-05-15T17:21:38+02:00 CORRESPONDENCE Re: MLH1 − 93G>A Promoter The Risk The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537 http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537 http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf text ftciteseerx 2016-01-08T11:46:42Z Raptis et al. ( 1) propose an association be-tween the MLH1 − 93G>A polymorphism and colorectal cancers with high micro-satellite instability (MSI-H) status and sug-gest that this variant is a low-penetrance allele for colorectal cancer susceptibility. Although it is plausible that, in addition to highly penetrant truncating mutations, com-mon variants of DNA mismatch repair genes such as MLH1 may contribute to colorectal cancer susceptibility, demonstrating causality is not straightforward. In the study of Raptis et al. ( 1), case patients with colorectal cancer were ascer-tained from the Ontario and Newfoundland Text Newfoundland Unknown |
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Raptis et al. ( 1) propose an association be-tween the MLH1 − 93G>A polymorphism and colorectal cancers with high micro-satellite instability (MSI-H) status and sug-gest that this variant is a low-penetrance allele for colorectal cancer susceptibility. Although it is plausible that, in addition to highly penetrant truncating mutations, com-mon variants of DNA mismatch repair genes such as MLH1 may contribute to colorectal cancer susceptibility, demonstrating causality is not straightforward. In the study of Raptis et al. ( 1), case patients with colorectal cancer were ascer-tained from the Ontario and Newfoundland |
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The Pennsylvania State University CiteSeerX Archives |
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The Risk |
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The Risk CORRESPONDENCE Re: MLH1 − 93G>A Promoter |
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The Risk |
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The Risk |
title |
CORRESPONDENCE Re: MLH1 − 93G>A Promoter |
title_short |
CORRESPONDENCE Re: MLH1 − 93G>A Promoter |
title_full |
CORRESPONDENCE Re: MLH1 − 93G>A Promoter |
title_fullStr |
CORRESPONDENCE Re: MLH1 − 93G>A Promoter |
title_full_unstemmed |
CORRESPONDENCE Re: MLH1 − 93G>A Promoter |
title_sort |
correspondence re: mlh1 − 93g>a promoter |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537 http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf |
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Newfoundland |
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Newfoundland |
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http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537 http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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