CORRESPONDENCE Re: MLH1 − 93G>A Promoter

Raptis et al. ( 1) propose an association be-tween the MLH1 − 93G>A polymorphism and colorectal cancers with high micro-satellite instability (MSI-H) status and sug-gest that this variant is a low-penetrance allele for colorectal cancer susceptibility. Although it is plausible that, in addition t...

Full description

Bibliographic Details
Main Author: The Risk
Other Authors: The Pennsylvania State University CiteSeerX Archives
Format: Text
Language:English
Subjects:
Online Access:http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537
http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf
id ftciteseerx:oai:CiteSeerX.psu:10.1.1.555.9537
record_format openpolar
spelling ftciteseerx:oai:CiteSeerX.psu:10.1.1.555.9537 2023-05-15T17:21:38+02:00 CORRESPONDENCE Re: MLH1 − 93G>A Promoter The Risk The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537 http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537 http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf text ftciteseerx 2016-01-08T11:46:42Z Raptis et al. ( 1) propose an association be-tween the MLH1 − 93G>A polymorphism and colorectal cancers with high micro-satellite instability (MSI-H) status and sug-gest that this variant is a low-penetrance allele for colorectal cancer susceptibility. Although it is plausible that, in addition to highly penetrant truncating mutations, com-mon variants of DNA mismatch repair genes such as MLH1 may contribute to colorectal cancer susceptibility, demonstrating causality is not straightforward. In the study of Raptis et al. ( 1), case patients with colorectal cancer were ascer-tained from the Ontario and Newfoundland Text Newfoundland Unknown
institution Open Polar
collection Unknown
op_collection_id ftciteseerx
language English
description Raptis et al. ( 1) propose an association be-tween the MLH1 − 93G>A polymorphism and colorectal cancers with high micro-satellite instability (MSI-H) status and sug-gest that this variant is a low-penetrance allele for colorectal cancer susceptibility. Although it is plausible that, in addition to highly penetrant truncating mutations, com-mon variants of DNA mismatch repair genes such as MLH1 may contribute to colorectal cancer susceptibility, demonstrating causality is not straightforward. In the study of Raptis et al. ( 1), case patients with colorectal cancer were ascer-tained from the Ontario and Newfoundland
author2 The Pennsylvania State University CiteSeerX Archives
format Text
author The Risk
spellingShingle The Risk
CORRESPONDENCE Re: MLH1 − 93G>A Promoter
author_facet The Risk
author_sort The Risk
title CORRESPONDENCE Re: MLH1 − 93G>A Promoter
title_short CORRESPONDENCE Re: MLH1 − 93G>A Promoter
title_full CORRESPONDENCE Re: MLH1 − 93G>A Promoter
title_fullStr CORRESPONDENCE Re: MLH1 − 93G>A Promoter
title_full_unstemmed CORRESPONDENCE Re: MLH1 − 93G>A Promoter
title_sort correspondence re: mlh1 − 93g>a promoter
url http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537
http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf
genre Newfoundland
genre_facet Newfoundland
op_source http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf
op_relation http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.9537
http://jnci.oxfordjournals.org/content/99/19/1490.1.full.pdf
op_rights Metadata may be used without restrictions as long as the oai identifier remains attached to it.
_version_ 1766106891172184064