EPIDEMIOLOGIC ASPECTS OF AMERICAN VISCERAL LEISHMANIASIS IN AN ENDEMIC FOCUS IN EASTERN VENEZUELA
Abstract. An endemic focus of American visceral leishmaniasis (AVL) in eastern Venezuela has been evaluated in terms of patients (n 5 48), immunologic reactivity to Leishmania in household contacts (n 5 187) and neighborhood controls (n 5 170), detection of Leishmania (L. donovani complex) in dogs a...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.555.484 2023-05-15T18:05:22+02:00 EPIDEMIOLOGIC ASPECTS OF AMERICAN VISCERAL LEISHMANIASIS IN AN ENDEMIC FOCUS IN EASTERN VENEZUELA Ana M. Zulueta Elena Villarroel Noris Rodriguez M. Dora Feliciangeli Milena Mazzarri Oscar Reyes Vestalia Rodriguez Marta Centeno Rosa M. Barrios Marian Ulrich The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.484 http://intl.ajtmh.org/content/61/6/945.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.484 http://intl.ajtmh.org/content/61/6/945.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://intl.ajtmh.org/content/61/6/945.full.pdf text ftciteseerx 2016-01-08T11:45:26Z Abstract. An endemic focus of American visceral leishmaniasis (AVL) in eastern Venezuela has been evaluated in terms of patients (n 5 48), immunologic reactivity to Leishmania in household contacts (n 5 187) and neighborhood controls (n 5 170), detection of Leishmania (L. donovani complex) in dogs and wild animals by the polymerase chain reaction (PCR) and characteristics of the sandfly population. The male:female ratio of patients was 1.18:1; 89.6 % were #12 years old. Serologic reactivity was significantly higher in household contacts than in controls (P 5 0.0008), as was the size of leishmanin reactions in contacts #10 years of age (P 5 0.0141). Leishmania donovani complex-specific PCRs were positive in dogs, an opossum (Didelphis marsupialis), and a black rat (Rattus rattus). Lutzomyia longipalpis and Lu. evansi, both implicated in the transmission of AVL, were identified among the 386 sand flies examined. These observations provide the bases for an active control program as well as further studies of reservoirs and vector-host relationships in this area. American visceral leishmaniasis (AVL) is caused by pro-tozoa of the Leishmania donovani complex and is endemic throughout much of Central and South America. The caus-ative agent in the Americas is considered to be L. chagasi sensu lato. Investigations in Brazil have shown that infection Text Rattus rattus Unknown |
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Abstract. An endemic focus of American visceral leishmaniasis (AVL) in eastern Venezuela has been evaluated in terms of patients (n 5 48), immunologic reactivity to Leishmania in household contacts (n 5 187) and neighborhood controls (n 5 170), detection of Leishmania (L. donovani complex) in dogs and wild animals by the polymerase chain reaction (PCR) and characteristics of the sandfly population. The male:female ratio of patients was 1.18:1; 89.6 % were #12 years old. Serologic reactivity was significantly higher in household contacts than in controls (P 5 0.0008), as was the size of leishmanin reactions in contacts #10 years of age (P 5 0.0141). Leishmania donovani complex-specific PCRs were positive in dogs, an opossum (Didelphis marsupialis), and a black rat (Rattus rattus). Lutzomyia longipalpis and Lu. evansi, both implicated in the transmission of AVL, were identified among the 386 sand flies examined. These observations provide the bases for an active control program as well as further studies of reservoirs and vector-host relationships in this area. American visceral leishmaniasis (AVL) is caused by pro-tozoa of the Leishmania donovani complex and is endemic throughout much of Central and South America. The caus-ative agent in the Americas is considered to be L. chagasi sensu lato. Investigations in Brazil have shown that infection |
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The Pennsylvania State University CiteSeerX Archives |
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Text |
author |
Ana M. Zulueta Elena Villarroel Noris Rodriguez M. Dora Feliciangeli Milena Mazzarri Oscar Reyes Vestalia Rodriguez Marta Centeno Rosa M. Barrios Marian Ulrich |
spellingShingle |
Ana M. Zulueta Elena Villarroel Noris Rodriguez M. Dora Feliciangeli Milena Mazzarri Oscar Reyes Vestalia Rodriguez Marta Centeno Rosa M. Barrios Marian Ulrich EPIDEMIOLOGIC ASPECTS OF AMERICAN VISCERAL LEISHMANIASIS IN AN ENDEMIC FOCUS IN EASTERN VENEZUELA |
author_facet |
Ana M. Zulueta Elena Villarroel Noris Rodriguez M. Dora Feliciangeli Milena Mazzarri Oscar Reyes Vestalia Rodriguez Marta Centeno Rosa M. Barrios Marian Ulrich |
author_sort |
Ana M. Zulueta |
title |
EPIDEMIOLOGIC ASPECTS OF AMERICAN VISCERAL LEISHMANIASIS IN AN ENDEMIC FOCUS IN EASTERN VENEZUELA |
title_short |
EPIDEMIOLOGIC ASPECTS OF AMERICAN VISCERAL LEISHMANIASIS IN AN ENDEMIC FOCUS IN EASTERN VENEZUELA |
title_full |
EPIDEMIOLOGIC ASPECTS OF AMERICAN VISCERAL LEISHMANIASIS IN AN ENDEMIC FOCUS IN EASTERN VENEZUELA |
title_fullStr |
EPIDEMIOLOGIC ASPECTS OF AMERICAN VISCERAL LEISHMANIASIS IN AN ENDEMIC FOCUS IN EASTERN VENEZUELA |
title_full_unstemmed |
EPIDEMIOLOGIC ASPECTS OF AMERICAN VISCERAL LEISHMANIASIS IN AN ENDEMIC FOCUS IN EASTERN VENEZUELA |
title_sort |
epidemiologic aspects of american visceral leishmaniasis in an endemic focus in eastern venezuela |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.484 http://intl.ajtmh.org/content/61/6/945.full.pdf |
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Rattus rattus |
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Rattus rattus |
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http://intl.ajtmh.org/content/61/6/945.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.484 http://intl.ajtmh.org/content/61/6/945.full.pdf |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766176836916609024 |