Mutational Bias in Penguin Microsatellite DNA
Analysis of nucleotide sequence variation at a microsatellite DNA locus revealed extensive size homoplasy of alleles in Adélie penguins (Pygoscelis adeliae). Variation in the flanking regions at this locus allowed discrimination between mechanisms proposed for length changes in microsatellite DNA a...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.548.4270 2023-05-15T18:03:49+02:00 Mutational Bias in Penguin Microsatellite DNA L. D. Shepherd D. M. Lambert The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.548.4270 http://jhered.oxfordjournals.org/content/96/5/566.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.548.4270 http://jhered.oxfordjournals.org/content/96/5/566.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://jhered.oxfordjournals.org/content/96/5/566.full.pdf text ftciteseerx 2016-01-08T11:23:59Z Analysis of nucleotide sequence variation at a microsatellite DNA locus revealed extensive size homoplasy of alleles in Adélie penguins (Pygoscelis adeliae). Variation in the flanking regions at this locus allowed discrimination between mechanisms proposed for length changes in microsatellite DNA alleles. We further examined the structure of alleles for the same microsatellite DNA locus across 11 additional species of penguin (Spheniscidae) by mapping allele sequen-ces onto an independent penguin phylogeny. Our analysis indicated that the repeat motifs appear to have evolved independently on several occasions. We observed sequence instability in the region bordering the repeat tract with a transversional bias predominating. We propose that this bias results from inaccurate DNA replication owing to the sequence context of this repeat tract. Because we show that regions flanking repeat sequences exhibit this mutational bias, this cautions against the use of such regions for phylogeny reconstruction. Text Pygoscelis adeliae Unknown |
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Open Polar |
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ftciteseerx |
language |
English |
description |
Analysis of nucleotide sequence variation at a microsatellite DNA locus revealed extensive size homoplasy of alleles in Adélie penguins (Pygoscelis adeliae). Variation in the flanking regions at this locus allowed discrimination between mechanisms proposed for length changes in microsatellite DNA alleles. We further examined the structure of alleles for the same microsatellite DNA locus across 11 additional species of penguin (Spheniscidae) by mapping allele sequen-ces onto an independent penguin phylogeny. Our analysis indicated that the repeat motifs appear to have evolved independently on several occasions. We observed sequence instability in the region bordering the repeat tract with a transversional bias predominating. We propose that this bias results from inaccurate DNA replication owing to the sequence context of this repeat tract. Because we show that regions flanking repeat sequences exhibit this mutational bias, this cautions against the use of such regions for phylogeny reconstruction. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
L. D. Shepherd D. M. Lambert |
spellingShingle |
L. D. Shepherd D. M. Lambert Mutational Bias in Penguin Microsatellite DNA |
author_facet |
L. D. Shepherd D. M. Lambert |
author_sort |
L. D. Shepherd |
title |
Mutational Bias in Penguin Microsatellite DNA |
title_short |
Mutational Bias in Penguin Microsatellite DNA |
title_full |
Mutational Bias in Penguin Microsatellite DNA |
title_fullStr |
Mutational Bias in Penguin Microsatellite DNA |
title_full_unstemmed |
Mutational Bias in Penguin Microsatellite DNA |
title_sort |
mutational bias in penguin microsatellite dna |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.548.4270 http://jhered.oxfordjournals.org/content/96/5/566.full.pdf |
genre |
Pygoscelis adeliae |
genre_facet |
Pygoscelis adeliae |
op_source |
http://jhered.oxfordjournals.org/content/96/5/566.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.548.4270 http://jhered.oxfordjournals.org/content/96/5/566.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766174838581362688 |