Dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.)
Saponins are naturally occurring amphiphilic molecules and have been associated with many biological activities. The aim of the present study was to investigate whether soya saponins trigger the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.), and to examine if dietary soya s...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.540.4056 2023-05-15T15:29:57+02:00 Dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.) David Knudsen Fredrik Jutfelt Henrik Sundh Kristina Sundell Hanne Frøkiær The Pennsylvania State University CiteSeerX Archives 2007 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.540.4056 http://www.zool.gu.se/digitalAssets/1060/1060895_Knudsen_Jutfelt_2007_soya_saponin_gut.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.540.4056 http://www.zool.gu.se/digitalAssets/1060/1060895_Knudsen_Jutfelt_2007_soya_saponin_gut.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://www.zool.gu.se/digitalAssets/1060/1060895_Knudsen_Jutfelt_2007_soya_saponin_gut.pdf text 2007 ftciteseerx 2016-01-08T11:02:28Z Saponins are naturally occurring amphiphilic molecules and have been associated with many biological activities. The aim of the present study was to investigate whether soya saponins trigger the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.), and to examine if dietary soya saponins increase the epithelial permeability of the distal intestine in Atlantic salmon. Seven experimental diets containing different levels of soya saponins were fed to seawater-adapted Atlantic salmon for 53 d. The diets included a fishmeal-based control diet, two fishmeal-based diets with different levels of added soya saponins, one diet containing 25 % lupin kernel meal, two diets based on 25 % lupin kernel meal with different levels of added soya saponins, and one diet containing 25 % defatted soyabean meal. The effect on intestinal morphology, intestinal epithelial permeability and faecal DM content was examined. Fish fed 25 % defatted soyabean meal displayed severe enteritis, whereas fish fed 25 % lupin kernel meal had normal intestinal morphology. The combination of soya saponins and fishmeal did not induce morphological changes but fish fed soya saponins in combination with lupin kernel meal displayed significant enteritis. Increased epithelial permeability was observed in fish fed 25 % defatted soyabean meal and in fish fed soya saponin concentrate independent of the protein source in the feed. The study demon-strates that soya saponins, in combination with one or several unidentified components present in legumes, induce an inflammatory reaction in the distal intestine of Atlantic salmon. Soya saponins increase the intestinal epithelial permeability but do not, per se, induce enteritis. Saponins: Enteritis: Barrier function: Diarrhoea Saponins are naturally occurring amphiphilic molecules con- Text Atlantic salmon Salmo salar Unknown |
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ftciteseerx |
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English |
description |
Saponins are naturally occurring amphiphilic molecules and have been associated with many biological activities. The aim of the present study was to investigate whether soya saponins trigger the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.), and to examine if dietary soya saponins increase the epithelial permeability of the distal intestine in Atlantic salmon. Seven experimental diets containing different levels of soya saponins were fed to seawater-adapted Atlantic salmon for 53 d. The diets included a fishmeal-based control diet, two fishmeal-based diets with different levels of added soya saponins, one diet containing 25 % lupin kernel meal, two diets based on 25 % lupin kernel meal with different levels of added soya saponins, and one diet containing 25 % defatted soyabean meal. The effect on intestinal morphology, intestinal epithelial permeability and faecal DM content was examined. Fish fed 25 % defatted soyabean meal displayed severe enteritis, whereas fish fed 25 % lupin kernel meal had normal intestinal morphology. The combination of soya saponins and fishmeal did not induce morphological changes but fish fed soya saponins in combination with lupin kernel meal displayed significant enteritis. Increased epithelial permeability was observed in fish fed 25 % defatted soyabean meal and in fish fed soya saponin concentrate independent of the protein source in the feed. The study demon-strates that soya saponins, in combination with one or several unidentified components present in legumes, induce an inflammatory reaction in the distal intestine of Atlantic salmon. Soya saponins increase the intestinal epithelial permeability but do not, per se, induce enteritis. Saponins: Enteritis: Barrier function: Diarrhoea Saponins are naturally occurring amphiphilic molecules con- |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
David Knudsen Fredrik Jutfelt Henrik Sundh Kristina Sundell Hanne Frøkiær |
spellingShingle |
David Knudsen Fredrik Jutfelt Henrik Sundh Kristina Sundell Hanne Frøkiær Dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.) |
author_facet |
David Knudsen Fredrik Jutfelt Henrik Sundh Kristina Sundell Hanne Frøkiær |
author_sort |
David Knudsen |
title |
Dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.) |
title_short |
Dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.) |
title_full |
Dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.) |
title_fullStr |
Dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.) |
title_full_unstemmed |
Dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in Atlantic salmon (Salmo salar L.) |
title_sort |
dietary soya saponins increase gut permeability and play a key role in the onset of soyabean-induced enteritis in atlantic salmon (salmo salar l.) |
publishDate |
2007 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.540.4056 http://www.zool.gu.se/digitalAssets/1060/1060895_Knudsen_Jutfelt_2007_soya_saponin_gut.pdf |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
http://www.zool.gu.se/digitalAssets/1060/1060895_Knudsen_Jutfelt_2007_soya_saponin_gut.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.540.4056 http://www.zool.gu.se/digitalAssets/1060/1060895_Knudsen_Jutfelt_2007_soya_saponin_gut.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766360409865977856 |