A combined analysis of the cystic fibrosis transmembrane conductance regulator: implications for structure and disease models

• Main Authors: Jian-min Chen, Chris Cutler, Caroline Jacques, Gilles Bœuf, Erick Denamur, Guillaume Lecointre, Bernard Mercier, Gordon Cramb
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Published: 2001
• Subjects: Giganteus; Atlantic salmon; Salmo salar
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.532.2813; http://mbe.oxfordjournals.org/content/18/9/1771.full.pdf

Over the past decade, nearly 1,000 variants have been identified in the cystic fibrosis transmembrane conductance regulator (CFTR) gene in classic and atypical cystic fibrosis (CF) patients worldwide, and an enormous wealth of information concerning the structure and function of the protein has also...