The renin–angiotensin system in blood pressure control during exercise in the cod, Gadus morhua
The effects of angiotensin I, angiotensin II and exercise on ventral and dorsal aortic blood pressure and heart rate were investigated in the Atlantic cod, Gadus morhua. Both angiotensins produced a marked increase in blood pressure. After injection of the angiotensin-converting enzyme (ACE) inhibit...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.518.5223 2023-05-15T15:27:35+02:00 The renin–angiotensin system in blood pressure control during exercise in the cod, Gadus morhua Björn Platzack Michael Axelsson Stefan Nilsson The Pennsylvania State University CiteSeerX Archives 1993 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.518.5223 http://jeb.biologists.org/content/180/1/253.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.518.5223 http://jeb.biologists.org/content/180/1/253.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://jeb.biologists.org/content/180/1/253.full.pdf text 1993 ftciteseerx 2016-01-08T09:58:49Z The effects of angiotensin I, angiotensin II and exercise on ventral and dorsal aortic blood pressure and heart rate were investigated in the Atlantic cod, Gadus morhua. Both angiotensins produced a marked increase in blood pressure. After injection of the angiotensin-converting enzyme (ACE) inhibitor enalapril, both ventral and dorsal blood pressures decreased significantly and the effect of angiotensin I was abolished. This demonstrates that ACE activity is necessay for conversion of angiotensin I to angiotensin II in the cod, as in other teleosts investigated, and provides a tool for further study of angiotensin function. During swimming exercise at 2/3 body lengths per second, ventral and dorsal aortic blood pressures increased, but this exercise hypertension was absent in fish pretreated with the a-adrenoceptor antagonist prazosin. Instead, an increase in both ventral and dorsal aortic blood pressures occurred immediately after the exercise period. This post-exercise hypertension could be abolished by injection of enalapril, suggesting that the angiotensin system is the responsible ‘anti-drop ’ factor activated in the absence of a functional adrenergic vasomotor control. We conclude that the angiotensin system provides a major contribution to the resting blood pressure regulation in the cod, and that this system can be activated to offset a decrease in arterial blood pressure. Text atlantic cod Gadus morhua Unknown |
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English |
description |
The effects of angiotensin I, angiotensin II and exercise on ventral and dorsal aortic blood pressure and heart rate were investigated in the Atlantic cod, Gadus morhua. Both angiotensins produced a marked increase in blood pressure. After injection of the angiotensin-converting enzyme (ACE) inhibitor enalapril, both ventral and dorsal blood pressures decreased significantly and the effect of angiotensin I was abolished. This demonstrates that ACE activity is necessay for conversion of angiotensin I to angiotensin II in the cod, as in other teleosts investigated, and provides a tool for further study of angiotensin function. During swimming exercise at 2/3 body lengths per second, ventral and dorsal aortic blood pressures increased, but this exercise hypertension was absent in fish pretreated with the a-adrenoceptor antagonist prazosin. Instead, an increase in both ventral and dorsal aortic blood pressures occurred immediately after the exercise period. This post-exercise hypertension could be abolished by injection of enalapril, suggesting that the angiotensin system is the responsible ‘anti-drop ’ factor activated in the absence of a functional adrenergic vasomotor control. We conclude that the angiotensin system provides a major contribution to the resting blood pressure regulation in the cod, and that this system can be activated to offset a decrease in arterial blood pressure. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Björn Platzack Michael Axelsson Stefan Nilsson |
spellingShingle |
Björn Platzack Michael Axelsson Stefan Nilsson The renin–angiotensin system in blood pressure control during exercise in the cod, Gadus morhua |
author_facet |
Björn Platzack Michael Axelsson Stefan Nilsson |
author_sort |
Björn Platzack |
title |
The renin–angiotensin system in blood pressure control during exercise in the cod, Gadus morhua |
title_short |
The renin–angiotensin system in blood pressure control during exercise in the cod, Gadus morhua |
title_full |
The renin–angiotensin system in blood pressure control during exercise in the cod, Gadus morhua |
title_fullStr |
The renin–angiotensin system in blood pressure control during exercise in the cod, Gadus morhua |
title_full_unstemmed |
The renin–angiotensin system in blood pressure control during exercise in the cod, Gadus morhua |
title_sort |
renin–angiotensin system in blood pressure control during exercise in the cod, gadus morhua |
publishDate |
1993 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.518.5223 http://jeb.biologists.org/content/180/1/253.full.pdf |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
http://jeb.biologists.org/content/180/1/253.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.518.5223 http://jeb.biologists.org/content/180/1/253.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766358011417198592 |