Manganese, copper and copper enzymes in blood of Icelandic sheep: Relevance to scrapie
The aim of this study was to investigate whether amounts of manganese or copper in blood, or the activity of copper enzymes (ceruloplasmin oxidative activity in serum and superoxide dismutase [SOD1] activity in erythrocytes) could be related to the sporadic occurrence of scrapie on sheep farms in Ic...
| Main Authors: | , , , , , |
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| Format: | Text |
| Language: | English |
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.508.488 http://www.landbunadur.is/landbunadur/wgsamvef.nsf/8bbba2777ac88c4000256a89000a2ddb/54055ec15974d519002570dd004d2a80/$FILE/Gr-bu18-THJ.pdf |
| Summary: | The aim of this study was to investigate whether amounts of manganese or copper in blood, or the activity of copper enzymes (ceruloplasmin oxidative activity in serum and superoxide dismutase [SOD1] activity in erythrocytes) could be related to the sporadic occurrence of scrapie on sheep farms in Iceland. The farms were divided into three Categories: Category 1: scrapie-free (never afflicted by scrapie, or prior to 1960 and then restocked with healthy sheep); Category 2: scrapie-prone (afflicted by scrapie after 1980 and restocked with healthy sheep); and Category 3: scrapie-afflicted (scrapie diagnosed in the respective flocks during the experimental period, autumn 2001 – autumn 2003). Blood samples were collected for analysis of manganese, copper and SOD1 activity from 2-5 year old ewes on 13 farms in all categories in the Vatnsdalur valley area in northern Iceland as well as from ewes on 3 scrapie-afflicted farms but located in other areas of the country. Ceruloplasmin oxidative activity was only analysed in serum from ewes in a preliminary study based on farms in all Categories in four different areas (the Vatnsdalur valley area inclu-sive). Manganese concentration in blood did not differ significantly between non-pregnant ewes on farms in the three Categories. The manganese concentration was not significantly different in blood of pregnant ewes on farms in the three Categories but it was significantly lower than in blood of the non-pregnant |
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