CLINICAL STUDY Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women
Objective: Hyperleptinaemia and hyperinsulinaemia interrelate to insulin-like growth factor binding protein 1 (IGFBP-1), and disturbances in the growth hormone–IGF-I axis are linked to obesity and cardiovascular diseases. However, whether the association between leptin and the GH–IGF-I axis is alter...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.498.8829 2023-05-15T17:44:42+02:00 CLINICAL STUDY Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women Mats Eliasson Bo Dinesen Kerstin Brismar Tommy Olsson The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.498.8829 http://www.eje-online.org/content/144/3/283.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.498.8829 http://www.eje-online.org/content/144/3/283.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://www.eje-online.org/content/144/3/283.full.pdf text ftciteseerx 2016-01-08T08:56:02Z Objective: Hyperleptinaemia and hyperinsulinaemia interrelate to insulin-like growth factor binding protein 1 (IGFBP-1), and disturbances in the growth hormone–IGF-I axis are linked to obesity and cardiovascular diseases. However, whether the association between leptin and the GH–IGF-I axis is altered with increasing obesity is not known. We therefore examined the relationship between leptin, IGF-I, IGFBP-1, insulin and proinsulin in men and women with or without obesity in a population study. Design and subjects: Healthy subjects n 158; 85 men and 73 pre- and postmenopausal women) from the Northern Sweden MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) population were studied with a cross-sectional design. Methods: Anthropometric measurements (body mass index (BMI) and waist circumference) and oral glucose tolerance tests were performed. Radioimmunoassays were used for the analyses of leptin, IGF-I and IGFBP-1, and ELISAs for specific insulin and proinsulin. Results: Leptin inversely correlated to IGFBP-1 in non-obese men P, 0:05 and obese postmenopausal women P, 0:05: In contrast, leptin did not correlate to IGF-I. IGFBP-1 was Text Northern Sweden Unknown |
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ftciteseerx |
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English |
description |
Objective: Hyperleptinaemia and hyperinsulinaemia interrelate to insulin-like growth factor binding protein 1 (IGFBP-1), and disturbances in the growth hormone–IGF-I axis are linked to obesity and cardiovascular diseases. However, whether the association between leptin and the GH–IGF-I axis is altered with increasing obesity is not known. We therefore examined the relationship between leptin, IGF-I, IGFBP-1, insulin and proinsulin in men and women with or without obesity in a population study. Design and subjects: Healthy subjects n 158; 85 men and 73 pre- and postmenopausal women) from the Northern Sweden MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) population were studied with a cross-sectional design. Methods: Anthropometric measurements (body mass index (BMI) and waist circumference) and oral glucose tolerance tests were performed. Radioimmunoassays were used for the analyses of leptin, IGF-I and IGFBP-1, and ELISAs for specific insulin and proinsulin. Results: Leptin inversely correlated to IGFBP-1 in non-obese men P, 0:05 and obese postmenopausal women P, 0:05: In contrast, leptin did not correlate to IGF-I. IGFBP-1 was |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Mats Eliasson Bo Dinesen Kerstin Brismar Tommy Olsson |
spellingShingle |
Mats Eliasson Bo Dinesen Kerstin Brismar Tommy Olsson CLINICAL STUDY Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
author_facet |
Mats Eliasson Bo Dinesen Kerstin Brismar Tommy Olsson |
author_sort |
Mats Eliasson |
title |
CLINICAL STUDY Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_short |
CLINICAL STUDY Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_full |
CLINICAL STUDY Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_fullStr |
CLINICAL STUDY Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_full_unstemmed |
CLINICAL STUDY Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
title_sort |
clinical study circulating igf binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.498.8829 http://www.eje-online.org/content/144/3/283.full.pdf |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
http://www.eje-online.org/content/144/3/283.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.498.8829 http://www.eje-online.org/content/144/3/283.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766146967423942656 |