5. Shy CM. The failure of academic epidemiology: witness for

• Main Authors: John E. Vena, Christine B. Ambrosone, Fred F. Kadlubar, Philip C. Nasca
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: Indian; Finnmark
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.494.2564; http://aje.oxfordjournals.org/content/149/11/1073.full.pdf

On the basis of 12 years of follow-up of 11,654 Norwegians aged 35-52 years, Nj0lstad et al. (1) recently reported that high density lipoprotein (HDL) cholesterol, controlled for potential confounders, was inversely associated with type 2 diabetes among women but not among men. These findings of a sex difference in HDL cholesterol as a protective factor for diabetes are consistent with an earlier study by Fagot-Campagna et al. (2) of 787 Pima Indians aged 15 years or older. Because of a high incidence of dia-betes (76 men and 185 women developed diabetes during 10 years), the Pima study had greater power to find a relation between lipoproteins and diabetes. Similar to the Finnmark finding (1), HDL cholesterol was inversely related to dia-betes incidence among Pima Indian women but not men, when controlled for age, body mass index, systolic blood