DOI:10.1093/aje/kwg222 Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women The Reykjavik Study
The relation between erythrocyte sedimentation rate (ESR) and risk of developing coronary heart disease (CHD) or fatal cerebrovascular accident was assessed in a cohort of 7,988 men and 8,685 women who participated in The Reykjavik Study (Iceland). Cardiovascular risk assessment was based on charact...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.489.4212 2023-05-15T16:51:11+02:00 DOI:10.1093/aje/kwg222 Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women The Reykjavik Study Am J Epidemiol Margret B. Andresdottir Nikulas Sigfusson Helgi Sigvaldason Vilmundur Gudnason The Pennsylvania State University CiteSeerX Archives 2002 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.489.4212 http://aje.oxfordjournals.org/content/158/9/844.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.489.4212 http://aje.oxfordjournals.org/content/158/9/844.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://aje.oxfordjournals.org/content/158/9/844.full.pdf text 2002 ftciteseerx 2016-01-08T08:22:46Z The relation between erythrocyte sedimentation rate (ESR) and risk of developing coronary heart disease (CHD) or fatal cerebrovascular accident was assessed in a cohort of 7,988 men and 8,685 women who participated in The Reykjavik Study (Iceland). Cardiovascular risk assessment was based on characteristics at baseline, from 1967 to 1996. During an average follow-up of 19 and 20 years, 2,092 men and 801 women, respectively, developed CHD, and 251 men and 178 women died from cerebrovascular accident. For men, the fully adjusted increase in risk of developing CHD predicted by the top compared with the bottom quintile of ESR was 57 % (hazard ratio = 1.57, 95 % confidence interval: 1.38, 1.78; p < 0.001); for women, risk was increased by 49 % (hazard ratio = 1.49, 95 % confidence interval: 1.16, 1.90; p < 0.001). The increased risk after baseline ESR measurement was stable for up to 25 years for men and 20 years for women. The fully adjusted risk of death due to stroke predicted by increasing the ln(ESR + 1) by one standard deviation was increased by 15 % for men (p = 0.06) and 16 % for women (p = 0.08). In conclusion, ESR is a long-term independent predictor of CHD in both men and women. These findings support the evidence of an inflammatory process in atherosclerosis. coronary disease; inflammation; risk factors Abbreviations: CHD, coronary heart disease; CI, confidence interval; ESR, erythrocyte sedimentation rate; HR, hazard ratio. It is evident that the traditionally known risk factors for Text Iceland Unknown |
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The relation between erythrocyte sedimentation rate (ESR) and risk of developing coronary heart disease (CHD) or fatal cerebrovascular accident was assessed in a cohort of 7,988 men and 8,685 women who participated in The Reykjavik Study (Iceland). Cardiovascular risk assessment was based on characteristics at baseline, from 1967 to 1996. During an average follow-up of 19 and 20 years, 2,092 men and 801 women, respectively, developed CHD, and 251 men and 178 women died from cerebrovascular accident. For men, the fully adjusted increase in risk of developing CHD predicted by the top compared with the bottom quintile of ESR was 57 % (hazard ratio = 1.57, 95 % confidence interval: 1.38, 1.78; p < 0.001); for women, risk was increased by 49 % (hazard ratio = 1.49, 95 % confidence interval: 1.16, 1.90; p < 0.001). The increased risk after baseline ESR measurement was stable for up to 25 years for men and 20 years for women. The fully adjusted risk of death due to stroke predicted by increasing the ln(ESR + 1) by one standard deviation was increased by 15 % for men (p = 0.06) and 16 % for women (p = 0.08). In conclusion, ESR is a long-term independent predictor of CHD in both men and women. These findings support the evidence of an inflammatory process in atherosclerosis. coronary disease; inflammation; risk factors Abbreviations: CHD, coronary heart disease; CI, confidence interval; ESR, erythrocyte sedimentation rate; HR, hazard ratio. It is evident that the traditionally known risk factors for |
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The Pennsylvania State University CiteSeerX Archives |
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Am J Epidemiol Margret B. Andresdottir Nikulas Sigfusson Helgi Sigvaldason Vilmundur Gudnason |
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Am J Epidemiol Margret B. Andresdottir Nikulas Sigfusson Helgi Sigvaldason Vilmundur Gudnason DOI:10.1093/aje/kwg222 Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women The Reykjavik Study |
author_facet |
Am J Epidemiol Margret B. Andresdottir Nikulas Sigfusson Helgi Sigvaldason Vilmundur Gudnason |
author_sort |
Am J Epidemiol |
title |
DOI:10.1093/aje/kwg222 Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women The Reykjavik Study |
title_short |
DOI:10.1093/aje/kwg222 Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women The Reykjavik Study |
title_full |
DOI:10.1093/aje/kwg222 Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women The Reykjavik Study |
title_fullStr |
DOI:10.1093/aje/kwg222 Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women The Reykjavik Study |
title_full_unstemmed |
DOI:10.1093/aje/kwg222 Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women The Reykjavik Study |
title_sort |
doi:10.1093/aje/kwg222 erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women the reykjavik study |
publishDate |
2002 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.489.4212 http://aje.oxfordjournals.org/content/158/9/844.full.pdf |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
http://aje.oxfordjournals.org/content/158/9/844.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.489.4212 http://aje.oxfordjournals.org/content/158/9/844.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766041289363554304 |