Correspondence
Ostreid herpesvirus 1 (OsHV-1) is the only member of the Herpesviridae that has an invertebrate host and is associated with sporadic mortality in the Pacific oyster (Crassostrea gigas) and other bivalve species. Cryo-electron microscopy of purified capsids revealed the distinctive T=16 icosahedral s...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.485.2075 2023-05-15T15:58:50+02:00 Correspondence Andrew J. Davison Benes L. Trus Naiqian Cheng Alasdair C. Steven Tristan Renault The Pennsylvania State University CiteSeerX Archives 2004 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.485.2075 http://vir.sgmjournals.org/content/86/1/41.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.485.2075 http://vir.sgmjournals.org/content/86/1/41.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://vir.sgmjournals.org/content/86/1/41.full.pdf text 2004 ftciteseerx 2016-01-08T08:08:36Z Ostreid herpesvirus 1 (OsHV-1) is the only member of the Herpesviridae that has an invertebrate host and is associated with sporadic mortality in the Pacific oyster (Crassostrea gigas) and other bivalve species. Cryo-electron microscopy of purified capsids revealed the distinctive T=16 icosahedral structure characteristic of herpesviruses, although the preparations examined lacked pentons. The gross genome organization ofOsHV-1was similar to that of certain mammalian herpesviruses (including herpes simplex virus and human cytomegalovirus), consisting of two invertible unique regions (UL, 167?8 kbp; US, 3?4 kbp) each flanked by inverted repeats (TRL/IRL, 7?6 kbp; TRS/IRS, 9?8 kbp), with an additional unique sequence (X, 1?5 kbp) between IRL and IRS. Of the 124 unique genes predicted from the 207439 bp genome sequence, 38 were members of 12 families of related genes and encoded products related to helicases, inhibitors of apoptosis, deoxyuridine triphosphatase and RING-finger proteins, in addition to membrane-associated proteins. Eight genes in three of the families appeared to be fragmented. Other genes that did not belong to the families were predicted to encode DNA polymerase, the two subunits of ribonucleotide reductase, a helicase, a primase, the ATPase subunit of terminase, a RecB-like protein, additional RING-like proteins, an ion channel and several other membrane-associated proteins. Sequence comparisons showed that OsHV-1 is at best tenuously related to the two classes of vertebrate herpesviruses (those associated with mammals, birds and reptiles, and those associated with bony fish and amphibians). OsHV-1 thus represents a third major class of the herpesviruses. Text Crassostrea gigas Pacific oyster Unknown Pacific |
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Ostreid herpesvirus 1 (OsHV-1) is the only member of the Herpesviridae that has an invertebrate host and is associated with sporadic mortality in the Pacific oyster (Crassostrea gigas) and other bivalve species. Cryo-electron microscopy of purified capsids revealed the distinctive T=16 icosahedral structure characteristic of herpesviruses, although the preparations examined lacked pentons. The gross genome organization ofOsHV-1was similar to that of certain mammalian herpesviruses (including herpes simplex virus and human cytomegalovirus), consisting of two invertible unique regions (UL, 167?8 kbp; US, 3?4 kbp) each flanked by inverted repeats (TRL/IRL, 7?6 kbp; TRS/IRS, 9?8 kbp), with an additional unique sequence (X, 1?5 kbp) between IRL and IRS. Of the 124 unique genes predicted from the 207439 bp genome sequence, 38 were members of 12 families of related genes and encoded products related to helicases, inhibitors of apoptosis, deoxyuridine triphosphatase and RING-finger proteins, in addition to membrane-associated proteins. Eight genes in three of the families appeared to be fragmented. Other genes that did not belong to the families were predicted to encode DNA polymerase, the two subunits of ribonucleotide reductase, a helicase, a primase, the ATPase subunit of terminase, a RecB-like protein, additional RING-like proteins, an ion channel and several other membrane-associated proteins. Sequence comparisons showed that OsHV-1 is at best tenuously related to the two classes of vertebrate herpesviruses (those associated with mammals, birds and reptiles, and those associated with bony fish and amphibians). OsHV-1 thus represents a third major class of the herpesviruses. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Andrew J. Davison Benes L. Trus Naiqian Cheng Alasdair C. Steven Tristan Renault |
spellingShingle |
Andrew J. Davison Benes L. Trus Naiqian Cheng Alasdair C. Steven Tristan Renault Correspondence |
author_facet |
Andrew J. Davison Benes L. Trus Naiqian Cheng Alasdair C. Steven Tristan Renault |
author_sort |
Andrew J. Davison |
title |
Correspondence |
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publishDate |
2004 |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.485.2075 http://vir.sgmjournals.org/content/86/1/41.full.pdf |
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Pacific |
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Pacific |
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Crassostrea gigas Pacific oyster |
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Crassostrea gigas Pacific oyster |
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http://vir.sgmjournals.org/content/86/1/41.full.pdf |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.485.2075 http://vir.sgmjournals.org/content/86/1/41.full.pdf |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766394611366887424 |