AMERICAN JOURNAL OF HUMAN BIOLOGY 18:766–775 (2006) Original Research Article High-Sensitivity C-Reactive Protein, Adiposity, and Blood Pressure in the Yakut of Siberia ABSTRACT

• Main Authors: M. V. Sorensen, W. R. Leonard, L. A. Tarskaya, K. I. Ivanov, J. J. Snodgrass, V. P. Alekseev, V. G. Krivoshapkin, N. Rifai
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: Yakut; Siberia
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.404.5579; http://www.pinniped.net/Sorensen2006.pdf

C-reactive protein (CRP), an acute-phase reactant and marker of inflammatory response, is known to be an important predictor of future cardiovascular mortality, independent of other risk factors. The purpose of this research was to investigate the association between CRP, adiposity, and blood pressure in the Yakut, an indigenous Siberian population undergoing rapid cultural change. We conducted a cross-sectional study of 265 healthy Yakut adults in six villages in rural northeastern Siberia. Plasma CRP was measured by high-sensitivity immunoturbidimetric assay. The median CRP value was 0.85 mg/l, with values for the 25th, 50th, and 75th percentiles of 0.30, 0.85, and 2.28 mg/l, respectively. CRP was positively associated with age (r 0.19; P 0.002), but not plasma lipids or smoking status. CRP was associated with measures of central adiposity and characteristics of the metabolic syndrome, particularly in women. We found significantly higher CRP across quintiles (Q) of waist circumference for women (difference 0.7 mg/l; P 0.035), but not men (difference 0.36 mg/l; P 0.515). CRP was significantly associated with systolic blood pressure in men (difference, Q1 vs. Q5 1.1 mg/ l; P 0.044) but not women (difference, Q1 vs. Q5 0.03 mg/l; P 0.713) after adjusting for age, waist circumference, and smoking status. CRP in the Yakut was considerably lower than