Author manuscript, published in "Infectious Disorders- Drug Targets (2008) 7 p." Innovative in silico approaches to address avian flu using grid
Abstract: The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation o...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.391.8322 2023-05-15T15:34:10+02:00 Author manuscript, published in "Infectious Disorders- Drug Targets (2008) 7 p." Innovative in silico approaches to address avian flu using grid Vincent Breton A Ana Lucia Da Costa Paul De Vlieger A Lydia Maigne A David Sarramia A Young-min Kim B Kim B Hon Quang Nguyen C Tony Solomonides D Yin-ta Wu E Truong Nam Hai F The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.391.8322 http://hal.archives-ouvertes.fr/docs/00/34/74/11/PDF/Innovativ.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.391.8322 http://hal.archives-ouvertes.fr/docs/00/34/74/11/PDF/Innovativ.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://hal.archives-ouvertes.fr/docs/00/34/74/11/PDF/Innovativ.pdf avian flu grid surveillance network virtual screening molecular epidemiology in2p3-00347411 version 1- 15 Dec 2008 text ftciteseerx 2016-01-08T02:17:33Z Abstract: The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper presents how we are currently exploring how to integrate the existing data sources towards a global surveillance network for molecular epidemiology. Text Avian flu Unknown |
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avian flu grid surveillance network virtual screening molecular epidemiology in2p3-00347411 version 1- 15 Dec 2008 |
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avian flu grid surveillance network virtual screening molecular epidemiology in2p3-00347411 version 1- 15 Dec 2008 Vincent Breton A Ana Lucia Da Costa Paul De Vlieger A Lydia Maigne A David Sarramia A Young-min Kim B Kim B Hon Quang Nguyen C Tony Solomonides D Yin-ta Wu E Truong Nam Hai F Author manuscript, published in "Infectious Disorders- Drug Targets (2008) 7 p." Innovative in silico approaches to address avian flu using grid |
topic_facet |
avian flu grid surveillance network virtual screening molecular epidemiology in2p3-00347411 version 1- 15 Dec 2008 |
description |
Abstract: The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper presents how we are currently exploring how to integrate the existing data sources towards a global surveillance network for molecular epidemiology. |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Vincent Breton A Ana Lucia Da Costa Paul De Vlieger A Lydia Maigne A David Sarramia A Young-min Kim B Kim B Hon Quang Nguyen C Tony Solomonides D Yin-ta Wu E Truong Nam Hai F |
author_facet |
Vincent Breton A Ana Lucia Da Costa Paul De Vlieger A Lydia Maigne A David Sarramia A Young-min Kim B Kim B Hon Quang Nguyen C Tony Solomonides D Yin-ta Wu E Truong Nam Hai F |
author_sort |
Vincent Breton A |
title |
Author manuscript, published in "Infectious Disorders- Drug Targets (2008) 7 p." Innovative in silico approaches to address avian flu using grid |
title_short |
Author manuscript, published in "Infectious Disorders- Drug Targets (2008) 7 p." Innovative in silico approaches to address avian flu using grid |
title_full |
Author manuscript, published in "Infectious Disorders- Drug Targets (2008) 7 p." Innovative in silico approaches to address avian flu using grid |
title_fullStr |
Author manuscript, published in "Infectious Disorders- Drug Targets (2008) 7 p." Innovative in silico approaches to address avian flu using grid |
title_full_unstemmed |
Author manuscript, published in "Infectious Disorders- Drug Targets (2008) 7 p." Innovative in silico approaches to address avian flu using grid |
title_sort |
author manuscript, published in "infectious disorders- drug targets (2008) 7 p." innovative in silico approaches to address avian flu using grid |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.391.8322 http://hal.archives-ouvertes.fr/docs/00/34/74/11/PDF/Innovativ.pdf |
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Avian flu |
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Avian flu |
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http://hal.archives-ouvertes.fr/docs/00/34/74/11/PDF/Innovativ.pdf |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.391.8322 http://hal.archives-ouvertes.fr/docs/00/34/74/11/PDF/Innovativ.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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