Complex Population Structure of Lyme Borreliosis Group Spirochete Borrelia garinii in Subarctic Eurasia
Borrelia garinii, a causative agent of Lyme borreliosis in Europe and Asia, is naturally maintained in marine and terrestrial enzootic cycles, which primarily involve birds, including seabirds and migratory passerines. These bird groups associate with, correspondingly, Ixodes uriae and Ixodes ricinu...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.358.7250 2023-05-15T15:12:18+02:00 Complex Population Structure of Lyme Borreliosis Group Spirochete Borrelia garinii in Subarctic Eurasia Pär Comstedt Loreta Asokliene Ingvar Eliasson Björn Olsen Anders Wallensten Jonas Bunikis Sven Bergström The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.7250 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.7250 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/68/e6/PLoS_ONE_2009_Jun_9_4(6)_e5841.tar.gz text ftciteseerx 2016-01-08T00:41:41Z Borrelia garinii, a causative agent of Lyme borreliosis in Europe and Asia, is naturally maintained in marine and terrestrial enzootic cycles, which primarily involve birds, including seabirds and migratory passerines. These bird groups associate with, correspondingly, Ixodes uriae and Ixodes ricinus ticks, of which the latter species may bite and transmit the infection to humans. Studies of the overlap between these two natural cycles of B. garinii have been limited, in part due to the absence of representative collections of this spirochete’s samples, as well as of the lack of reliable measure of the genetic heterogeneity of its strains. As a prerequisite for understanding the epidemiological correlates of the complex maintenance of B. garinii, the present study sought to assess the diversity and phylogenetic relationships of this species ’ strains from its natural hosts and patients with Lyme borreliosis from subarctic Eurasia. We used sequence typing of the partial rrs-rrl intergenic spacer (IGS) of archived and prospective samples of B. garinii from I. uriae ticks collected predominantly on Commander Islands in North Pacific, as well as on the islands in northern Sweden and arctic Norway. We also typed B. garinii samples from patients with Lyme borreliosis and I. ricinus ticks infesting migratory birds in southern Sweden, or found questing in selected sites on the islands in the Baltic Sea and Lithuania. Fifty-two (68%) of 77 B. garinii samples representing wide geographical range and associated with I. ricinus and infection of humans contributed 12 (60%) of total 20 identified IGS variants. In contrast, the remaining 25 (32%) samples recovered from I. uriae ticks from a few islands accounted for as Text Arctic Northern Sweden Subarctic Unknown Arctic Norway Pacific |
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Open Polar |
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English |
description |
Borrelia garinii, a causative agent of Lyme borreliosis in Europe and Asia, is naturally maintained in marine and terrestrial enzootic cycles, which primarily involve birds, including seabirds and migratory passerines. These bird groups associate with, correspondingly, Ixodes uriae and Ixodes ricinus ticks, of which the latter species may bite and transmit the infection to humans. Studies of the overlap between these two natural cycles of B. garinii have been limited, in part due to the absence of representative collections of this spirochete’s samples, as well as of the lack of reliable measure of the genetic heterogeneity of its strains. As a prerequisite for understanding the epidemiological correlates of the complex maintenance of B. garinii, the present study sought to assess the diversity and phylogenetic relationships of this species ’ strains from its natural hosts and patients with Lyme borreliosis from subarctic Eurasia. We used sequence typing of the partial rrs-rrl intergenic spacer (IGS) of archived and prospective samples of B. garinii from I. uriae ticks collected predominantly on Commander Islands in North Pacific, as well as on the islands in northern Sweden and arctic Norway. We also typed B. garinii samples from patients with Lyme borreliosis and I. ricinus ticks infesting migratory birds in southern Sweden, or found questing in selected sites on the islands in the Baltic Sea and Lithuania. Fifty-two (68%) of 77 B. garinii samples representing wide geographical range and associated with I. ricinus and infection of humans contributed 12 (60%) of total 20 identified IGS variants. In contrast, the remaining 25 (32%) samples recovered from I. uriae ticks from a few islands accounted for as |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Pär Comstedt Loreta Asokliene Ingvar Eliasson Björn Olsen Anders Wallensten Jonas Bunikis Sven Bergström |
spellingShingle |
Pär Comstedt Loreta Asokliene Ingvar Eliasson Björn Olsen Anders Wallensten Jonas Bunikis Sven Bergström Complex Population Structure of Lyme Borreliosis Group Spirochete Borrelia garinii in Subarctic Eurasia |
author_facet |
Pär Comstedt Loreta Asokliene Ingvar Eliasson Björn Olsen Anders Wallensten Jonas Bunikis Sven Bergström |
author_sort |
Pär Comstedt |
title |
Complex Population Structure of Lyme Borreliosis Group Spirochete Borrelia garinii in Subarctic Eurasia |
title_short |
Complex Population Structure of Lyme Borreliosis Group Spirochete Borrelia garinii in Subarctic Eurasia |
title_full |
Complex Population Structure of Lyme Borreliosis Group Spirochete Borrelia garinii in Subarctic Eurasia |
title_fullStr |
Complex Population Structure of Lyme Borreliosis Group Spirochete Borrelia garinii in Subarctic Eurasia |
title_full_unstemmed |
Complex Population Structure of Lyme Borreliosis Group Spirochete Borrelia garinii in Subarctic Eurasia |
title_sort |
complex population structure of lyme borreliosis group spirochete borrelia garinii in subarctic eurasia |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.7250 |
geographic |
Arctic Norway Pacific |
geographic_facet |
Arctic Norway Pacific |
genre |
Arctic Northern Sweden Subarctic |
genre_facet |
Arctic Northern Sweden Subarctic |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/68/e6/PLoS_ONE_2009_Jun_9_4(6)_e5841.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.7250 |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766343003061878784 |