Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level
We tested the metabolic rate hypothesis (whereby rates of mtDNA evolution are postulated to be mediated primarily by mutagenic by-products of respiration) by examining whether mass-specific metabolic rate was correlated with root-to-tip distance on a set of mtDNA trees for the springtail Cryptopygus...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.354.5804 2023-05-15T13:32:25+02:00 Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level Angela Mcgaughran Barbara R. Holl The Pennsylvania State University CiteSeerX Archives 2009 application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.5804 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.5804 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0a/75/PLoS_One_2010_Mar_15_5(3)_e9686.tar.gz text 2009 ftciteseerx 2016-01-08T00:30:27Z We tested the metabolic rate hypothesis (whereby rates of mtDNA evolution are postulated to be mediated primarily by mutagenic by-products of respiration) by examining whether mass-specific metabolic rate was correlated with root-to-tip distance on a set of mtDNA trees for the springtail Cryptopygus antarcticus travei from sub-Antarctic Marion Island. Using Bayesian analyses and a novel application of the comparative phylogenetic method, we did not find significant evidence that contemporary metabolic rates directly correlate with mutation rate (i.e., root-to-tip distance) once the underlying phylogeny is taken into account. However, we did find significant evidence that metabolic rate is dependent on the underlying mtDNA tree, or in other words, lineages with related mtDNA also have similar metabolic rates. We anticipate that future analyses which apply this methodology to datasets with longer sequences, more taxa, or greater variability will have more power to detect a significant direct correlation between metabolic rate and mutation rate. We conclude with suggestions for future analyses that would extend the preliminary approach applied here, in particular highlighting ways to tease apart oxidative stress effects from the effects of population size and/or selection coefficients operating on the molecular evolutionary rate. Text Antarc* Antarctic antarcticus Cryptopygus antarcticus Marion Island Springtail Unknown Antarctic |
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ftciteseerx |
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English |
description |
We tested the metabolic rate hypothesis (whereby rates of mtDNA evolution are postulated to be mediated primarily by mutagenic by-products of respiration) by examining whether mass-specific metabolic rate was correlated with root-to-tip distance on a set of mtDNA trees for the springtail Cryptopygus antarcticus travei from sub-Antarctic Marion Island. Using Bayesian analyses and a novel application of the comparative phylogenetic method, we did not find significant evidence that contemporary metabolic rates directly correlate with mutation rate (i.e., root-to-tip distance) once the underlying phylogeny is taken into account. However, we did find significant evidence that metabolic rate is dependent on the underlying mtDNA tree, or in other words, lineages with related mtDNA also have similar metabolic rates. We anticipate that future analyses which apply this methodology to datasets with longer sequences, more taxa, or greater variability will have more power to detect a significant direct correlation between metabolic rate and mutation rate. We conclude with suggestions for future analyses that would extend the preliminary approach applied here, in particular highlighting ways to tease apart oxidative stress effects from the effects of population size and/or selection coefficients operating on the molecular evolutionary rate. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Angela Mcgaughran Barbara R. Holl |
spellingShingle |
Angela Mcgaughran Barbara R. Holl Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level |
author_facet |
Angela Mcgaughran Barbara R. Holl |
author_sort |
Angela Mcgaughran |
title |
Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level |
title_short |
Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level |
title_full |
Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level |
title_fullStr |
Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level |
title_full_unstemmed |
Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level |
title_sort |
testing the effect of metabolic rate on dna variability at the intra-specific level |
publishDate |
2009 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.5804 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic antarcticus Cryptopygus antarcticus Marion Island Springtail |
genre_facet |
Antarc* Antarctic antarcticus Cryptopygus antarcticus Marion Island Springtail |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0a/75/PLoS_One_2010_Mar_15_5(3)_e9686.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.5804 |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766026952791031808 |