Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One 5:e11487
Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fat...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.354.1301 2023-05-15T15:31:22+02:00 Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One 5:e11487 Gustavo Palacios Marie Lovoll Torstein Tengs Mady Hornig Stephen Hutchison Jeffrey Hui Ruth-torill Kongtorp Nazir Savji Ana V. Bussetti Er Solovyov Anja B. Kristoffersen Christopher Celone Craig Street Vladimir Trifonov David L. Hirschberg Raul Rabadan Espen Rimstad W. Ian Lipkin The Pennsylvania State University CiteSeerX Archives 2010 application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.1301 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.1301 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/31/84/PLoS_One_2010_Jul_9_5(7)_e11487.tar.gz text 2010 ftciteseerx 2016-01-08T00:29:06Z Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fatal disease of farmed Atlantic salmon. First recognized in one farm in Norway in 1999[1], HSMI was subsequently implicated in outbreaks in other farms in Norway and the United Kingdom[2]. Although pathology and disease transmission studies indicated an infectious basis, efforts to identify an agent were unsuccessful. Here we provide evidence that HSMI is associated with infection with piscine reovirus (PRV). PRV is a novel reovirus identified by unbiased high throughput DNA sequencing and a bioinformatics program focused on nucleotide frequency as well as sequence alignment and motif analyses. Formal implication of PRV in HSMI will require isolation in cell culture and fulfillment of Koch’s postulates, or prevention or modification of disease through use of specific drugs or vaccines. Nonetheless, as our data indicate that a causal relationship is plausible, measures must be taken to control PRV not only because it threatens domestic salmon production but also due to the potential for transmission to wild salmon Text Atlantic salmon Salmo salar Unknown Norway |
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English |
description |
Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fatal disease of farmed Atlantic salmon. First recognized in one farm in Norway in 1999[1], HSMI was subsequently implicated in outbreaks in other farms in Norway and the United Kingdom[2]. Although pathology and disease transmission studies indicated an infectious basis, efforts to identify an agent were unsuccessful. Here we provide evidence that HSMI is associated with infection with piscine reovirus (PRV). PRV is a novel reovirus identified by unbiased high throughput DNA sequencing and a bioinformatics program focused on nucleotide frequency as well as sequence alignment and motif analyses. Formal implication of PRV in HSMI will require isolation in cell culture and fulfillment of Koch’s postulates, or prevention or modification of disease through use of specific drugs or vaccines. Nonetheless, as our data indicate that a causal relationship is plausible, measures must be taken to control PRV not only because it threatens domestic salmon production but also due to the potential for transmission to wild salmon |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Gustavo Palacios Marie Lovoll Torstein Tengs Mady Hornig Stephen Hutchison Jeffrey Hui Ruth-torill Kongtorp Nazir Savji Ana V. Bussetti Er Solovyov Anja B. Kristoffersen Christopher Celone Craig Street Vladimir Trifonov David L. Hirschberg Raul Rabadan Espen Rimstad W. Ian Lipkin |
spellingShingle |
Gustavo Palacios Marie Lovoll Torstein Tengs Mady Hornig Stephen Hutchison Jeffrey Hui Ruth-torill Kongtorp Nazir Savji Ana V. Bussetti Er Solovyov Anja B. Kristoffersen Christopher Celone Craig Street Vladimir Trifonov David L. Hirschberg Raul Rabadan Espen Rimstad W. Ian Lipkin Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One 5:e11487 |
author_facet |
Gustavo Palacios Marie Lovoll Torstein Tengs Mady Hornig Stephen Hutchison Jeffrey Hui Ruth-torill Kongtorp Nazir Savji Ana V. Bussetti Er Solovyov Anja B. Kristoffersen Christopher Celone Craig Street Vladimir Trifonov David L. Hirschberg Raul Rabadan Espen Rimstad W. Ian Lipkin |
author_sort |
Gustavo Palacios |
title |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One 5:e11487 |
title_short |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One 5:e11487 |
title_full |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One 5:e11487 |
title_fullStr |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One 5:e11487 |
title_full_unstemmed |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One 5:e11487 |
title_sort |
heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. plos one 5:e11487 |
publishDate |
2010 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.1301 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/31/84/PLoS_One_2010_Jul_9_5(7)_e11487.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.1301 |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766361867052122112 |