and Cardiovascular Disease
OBJECTIVE — A1C has been proposed as a new indicator for high risk of type 2 diabetes. The long-term predictive power and comparability of elevated A1C with the currently used high-risk indicators remain unclear. We assessed A1C, impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) a...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.351.6120 2023-05-15T17:42:50+02:00 and Cardiovascular Disease Ulla Rajala The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.6120 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.6120 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4f/8b/Diabetes_Care_2010_Sep_23_33(9)_2077-2083.tar.gz text ftciteseerx 2016-01-08T00:22:39Z OBJECTIVE — A1C has been proposed as a new indicator for high risk of type 2 diabetes. The long-term predictive power and comparability of elevated A1C with the currently used high-risk indicators remain unclear. We assessed A1C, impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) as predictors of type 2 diabetes and cardiovascular disease (CVD) at 10 years. RESEARCH DESIGN AND METHODS — This prospective population-based study of 593 inhabitants from northern Finland, born in 1935, was conducted between 1996 and 2008. An oral glucose tolerance test (OGTT) was conducted at baseline and follow-up, and A1C was determined at baseline. Those with a history of diabetes were excluded from the study. Elevated A1C was defined as 5.7–6.4%. Incident type 2 diabetes was confirmed by two OGTTs. Cardiovascular outcome was measured as incident CVD or CVD mortality. Multivariate log-binomial regression models were used to predict diabetes, CVD, and CVD mortality at 10 years. Receiver operating characteristic curves compared predictive values of A1C, IGT, and IFG. RESULTS — Incidence of diabetes during the follow-up was 17.1%. Two of three of the cases of newly diagnosed diabetes were predicted by a raise in �1 of the markers. Elevated A1C, IGT, or IFG preceded diabetes in 32.8, 40.6, and 21.9%, respectively. CVD was predicted by an intermediate and diabetic range of 2-h glucose but only by diabetic A1C levels in women. CONCLUSIONS — A1C predicted 10-year risk of type 2 diabetes at a range of A1C 5.7– 6.4 % but CVD only in women at A1C �6.5%. Early detection of high risk for type 2 diabetes is fundamental for prevention of diabetes and associated cardiovascular complications. Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are currently used for diagnosis of high-risk glucose levels below the diabetic range. The International Expert Committee proposed A1C �6.5 % as a diagnostic tool for diabetes in Text Northern Finland Unknown |
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OBJECTIVE — A1C has been proposed as a new indicator for high risk of type 2 diabetes. The long-term predictive power and comparability of elevated A1C with the currently used high-risk indicators remain unclear. We assessed A1C, impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) as predictors of type 2 diabetes and cardiovascular disease (CVD) at 10 years. RESEARCH DESIGN AND METHODS — This prospective population-based study of 593 inhabitants from northern Finland, born in 1935, was conducted between 1996 and 2008. An oral glucose tolerance test (OGTT) was conducted at baseline and follow-up, and A1C was determined at baseline. Those with a history of diabetes were excluded from the study. Elevated A1C was defined as 5.7–6.4%. Incident type 2 diabetes was confirmed by two OGTTs. Cardiovascular outcome was measured as incident CVD or CVD mortality. Multivariate log-binomial regression models were used to predict diabetes, CVD, and CVD mortality at 10 years. Receiver operating characteristic curves compared predictive values of A1C, IGT, and IFG. RESULTS — Incidence of diabetes during the follow-up was 17.1%. Two of three of the cases of newly diagnosed diabetes were predicted by a raise in �1 of the markers. Elevated A1C, IGT, or IFG preceded diabetes in 32.8, 40.6, and 21.9%, respectively. CVD was predicted by an intermediate and diabetic range of 2-h glucose but only by diabetic A1C levels in women. CONCLUSIONS — A1C predicted 10-year risk of type 2 diabetes at a range of A1C 5.7– 6.4 % but CVD only in women at A1C �6.5%. Early detection of high risk for type 2 diabetes is fundamental for prevention of diabetes and associated cardiovascular complications. Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are currently used for diagnosis of high-risk glucose levels below the diabetic range. The International Expert Committee proposed A1C �6.5 % as a diagnostic tool for diabetes in |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Ulla Rajala |
spellingShingle |
Ulla Rajala and Cardiovascular Disease |
author_facet |
Ulla Rajala |
author_sort |
Ulla Rajala |
title |
and Cardiovascular Disease |
title_short |
and Cardiovascular Disease |
title_full |
and Cardiovascular Disease |
title_fullStr |
and Cardiovascular Disease |
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and Cardiovascular Disease |
title_sort |
and cardiovascular disease |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.6120 |
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Northern Finland |
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Northern Finland |
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ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4f/8b/Diabetes_Care_2010_Sep_23_33(9)_2077-2083.tar.gz |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.6120 |
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1766144760610816000 |