Research | Children’s Health Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants
Ba c k g r o u n d: Polychlorinated biphenyls (PCBs) may cause immunotoxic effects, but the detailed dose–response relationship and possible vulnerable time windows of exposure are uncertain. In this study we applied serum concentrations of specific antibodies against childhood vaccines as sentinels...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.351.1328 2023-05-15T16:10:54+02:00 Research | Children’s Health Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants Carsten Heilmann Esben Budtz-jørgensen Flemming Nielsen Birger Heinzow Pál Weihe The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.1328 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.1328 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/61/ee/Environ_Health_Perspect_2010_Oct_20_118(10)_1434-1438.tar.gz text ftciteseerx 2016-01-08T00:21:13Z Ba c k g r o u n d: Polychlorinated biphenyls (PCBs) may cause immunotoxic effects, but the detailed dose–response relationship and possible vulnerable time windows of exposure are uncertain. In this study we applied serum concentrations of specific antibodies against childhood vaccines as sentinels of immunotoxicity. Objectives: The main objective was to assess the possible dependence of antibody concentrations against diphtheria and tetanus toxoids in children with regard to prenatal and postnatal PCB exposures. Met h o d s: From a cohort of 656 singleton births formed in the Faroe Islands during 1999–2001, children were invited for examination with assessment of serum antibody concentrations at 5 years (before and after a booster vaccination) and at 7 years of age. Total PCB concentrations were determined in serum from ages 5 and 7 years, and data were also available on PCB concentrations in maternal pregnancy serum, maternal milk, and, for a subgroup, the child’s serum at 18 months of age. Re s u l t s: A total of 587 children participated in the examinations at ages 5 and/or 7 years. At age 5 years, before the booster vaccination, the antidiphtheria antibody concentration was inversely associated with PCB concentrations in milk and 18-month serum. Results obtained 2 years later showed an inverse association of concentrations of antibodies against both toxoids with PCB concentrations Text Faroe Islands Unknown Faroe Islands |
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Ba c k g r o u n d: Polychlorinated biphenyls (PCBs) may cause immunotoxic effects, but the detailed dose–response relationship and possible vulnerable time windows of exposure are uncertain. In this study we applied serum concentrations of specific antibodies against childhood vaccines as sentinels of immunotoxicity. Objectives: The main objective was to assess the possible dependence of antibody concentrations against diphtheria and tetanus toxoids in children with regard to prenatal and postnatal PCB exposures. Met h o d s: From a cohort of 656 singleton births formed in the Faroe Islands during 1999–2001, children were invited for examination with assessment of serum antibody concentrations at 5 years (before and after a booster vaccination) and at 7 years of age. Total PCB concentrations were determined in serum from ages 5 and 7 years, and data were also available on PCB concentrations in maternal pregnancy serum, maternal milk, and, for a subgroup, the child’s serum at 18 months of age. Re s u l t s: A total of 587 children participated in the examinations at ages 5 and/or 7 years. At age 5 years, before the booster vaccination, the antidiphtheria antibody concentration was inversely associated with PCB concentrations in milk and 18-month serum. Results obtained 2 years later showed an inverse association of concentrations of antibodies against both toxoids with PCB concentrations |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Carsten Heilmann Esben Budtz-jørgensen Flemming Nielsen Birger Heinzow Pál Weihe |
spellingShingle |
Carsten Heilmann Esben Budtz-jørgensen Flemming Nielsen Birger Heinzow Pál Weihe Research | Children’s Health Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants |
author_facet |
Carsten Heilmann Esben Budtz-jørgensen Flemming Nielsen Birger Heinzow Pál Weihe |
author_sort |
Carsten Heilmann |
title |
Research | Children’s Health Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants |
title_short |
Research | Children’s Health Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants |
title_full |
Research | Children’s Health Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants |
title_fullStr |
Research | Children’s Health Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants |
title_full_unstemmed |
Research | Children’s Health Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed Perinatally to Immunotoxicants |
title_sort |
research | children’s health serum concentrations of antibodies against vaccine toxoids in children exposed perinatally to immunotoxicants |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.1328 |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
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ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/61/ee/Environ_Health_Perspect_2010_Oct_20_118(10)_1434-1438.tar.gz |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.1328 |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1765996039301496832 |