Blackwell Publishing Ltd of closely linked SNPs

• Main Authors: Raphaël Leblois, Montgomery Slatkin
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Published: 2007
• Subjects: coalescent theory; founder effect; gene genealogy; linkage disequilibrium; maximumlikelihood estimation; Canis lupus
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.324.2268; http://ib.berkeley.edu/labs/slatkin/monty/LebloisSlatkinMolEcol2007.pdf

We consider an isolated population founded by a small number of individuals randomly chosen from a source population of known genetic composition at a known time in the past. We develop a Monte-Carlo maximum-likelihood method for estimating the number of founding individuals from the haplotype frequencies at several SNP (single nucleotide polymorphism) loci in a sample. We assume the isolated population was founded recently enough that that mutation can be ignored and that haplotype frequencies in the source population have not changed. We apply the method to simulated data and show that it is unbiased. With a reasonable number of individuals sampled, it is possible to estimate the number of founders within a factor of 2. We show that the performance of the method is not degraded substantially if the frequencies of the rare haplotypes in the source are not known precisely and if there is some recombination. We illustrate the use of our method by applying it to a previously published data set from a recently founded population of wolves (Canis lupus) in Scandinavia.