Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears
Copyright © 2008 by the American Physiological Society. Cardiac titin isoform switching in hibernating bears 2 The hibernation phenomenon captures biological as well as clinical interests to understand how organs adapt. Here we studied how hibernating grizzly bears (Ursus arctos horribilis) tolerate...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.321.3787 2023-05-15T18:42:04+02:00 Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears O. Lynne Nelson Charles T. Robbins Yiming Wu Henk Granzier The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.3787 http://ajpheart.physiology.org/content/early/2008/05/23/ajpheart.00234.2008.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.3787 http://ajpheart.physiology.org/content/early/2008/05/23/ajpheart.00234.2008.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://ajpheart.physiology.org/content/early/2008/05/23/ajpheart.00234.2008.full.pdf text ftciteseerx 2016-09-04T00:20:30Z Copyright © 2008 by the American Physiological Society. Cardiac titin isoform switching in hibernating bears 2 The hibernation phenomenon captures biological as well as clinical interests to understand how organs adapt. Here we studied how hibernating grizzly bears (Ursus arctos horribilis) tolerate extremely low heart rates without developing cardiac chamber dilation. We evaluated cardiac filling function in unanesthetized grizzly bears by echocardiography during the active and hibernating period. Because both collagen and titin are involved in altering diastolic function, we investigated both in the myocardium of active and hibernating grizzly bears. Heart rates were reduced from 84 bpm in active bears to 19 bpm in hibernating bears. Diastolic volume, stroke volume and left ventricular ejection fraction were not different. However, left ventricular muscle mass was significantly lower in the hibernating bears 300 ± 12 compared to 402 ± 14 grams (p = 0.003), and as a result the diastolic volume to left ventricular muscle mass ratio was significantly greater. Early ventricular filling deceleration times were shorter during hibernation, 106.4 ± 14 compared to 143.2 ± 20 ms (p = 0.002) suggesting Text Ursus arctos Unknown |
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description |
Copyright © 2008 by the American Physiological Society. Cardiac titin isoform switching in hibernating bears 2 The hibernation phenomenon captures biological as well as clinical interests to understand how organs adapt. Here we studied how hibernating grizzly bears (Ursus arctos horribilis) tolerate extremely low heart rates without developing cardiac chamber dilation. We evaluated cardiac filling function in unanesthetized grizzly bears by echocardiography during the active and hibernating period. Because both collagen and titin are involved in altering diastolic function, we investigated both in the myocardium of active and hibernating grizzly bears. Heart rates were reduced from 84 bpm in active bears to 19 bpm in hibernating bears. Diastolic volume, stroke volume and left ventricular ejection fraction were not different. However, left ventricular muscle mass was significantly lower in the hibernating bears 300 ± 12 compared to 402 ± 14 grams (p = 0.003), and as a result the diastolic volume to left ventricular muscle mass ratio was significantly greater. Early ventricular filling deceleration times were shorter during hibernation, 106.4 ± 14 compared to 143.2 ± 20 ms (p = 0.002) suggesting |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
O. Lynne Nelson Charles T. Robbins Yiming Wu Henk Granzier |
spellingShingle |
O. Lynne Nelson Charles T. Robbins Yiming Wu Henk Granzier Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears |
author_facet |
O. Lynne Nelson Charles T. Robbins Yiming Wu Henk Granzier |
author_sort |
O. Lynne Nelson |
title |
Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears |
title_short |
Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears |
title_full |
Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears |
title_fullStr |
Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears |
title_full_unstemmed |
Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears |
title_sort |
titin isoform switching is a major cardiac adaptive response in hibernating grizzly bears |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.3787 http://ajpheart.physiology.org/content/early/2008/05/23/ajpheart.00234.2008.full.pdf |
genre |
Ursus arctos |
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Ursus arctos |
op_source |
http://ajpheart.physiology.org/content/early/2008/05/23/ajpheart.00234.2008.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.3787 http://ajpheart.physiology.org/content/early/2008/05/23/ajpheart.00234.2008.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766231670836428800 |